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تم العثور علي : 8
 تم العثور علي : 8
  
 
إعادة البحث

Thesis 2017.
Awad, Basma Mosilhy Kassem.
615 علم الصيدلة والعلاج  
pharmacy - Abstract:
Historically - plants have been used since ancient times and in folklore for the treatment of many diseases and illnesses including chronic diseases and cancer care. In recent years - plants have been getting more attention as drugs worldwide.
Achillea fragrantissima (Forssk.) Sch. Bip. is a desert plant which belongs to Asteraceae family and is known as Qaysūm in Arabic. We selected it as a member of family Asteraceae to be the plant under investigation. It grows in Sinai - Egypt and is used in folk medicine by Bedouins for treatment of many diseases. In addition it has been tested for its anticancer activity. The broad aim of this thesis was to conduct a phytochemical investigation and biological confirmation of the plant Achillea fragrantissima (Forssk.) Sch. Bip. and its constituents as an anticancer agents illustrating their mechanism of action.
The initial part of this work focused on large scale extraction of the plant with different solvents - bioactivity-guided fractionation led to the isolation of seven compounds followed by determination of the chemical nature of them. The isolated compounds are:
The known compounds Eupatilin 7- methyl ether (3) - chrysosplenol D (4) - Cirsiliol (5) - β-Sitosterol-3-O-β-D-glucoside (6) and Cirsimaritin (7) while Piceol (1) and Veratric acid (2) are reported here for the first time from Achillea fragrantissima (Forssk.) Sch. Bip.
The second part of this work focused on evaluation of the in-vitro cytotoxic activity of the methanolic extract of A. fragrantissima (Forssk.) Sch. Bip - its fractions and the isolated compounds 1 - 2 - 3 - 4 - 5 and 7 against different cell lines using the Sulpho-Rhodamine-B (SRB) assay. The extract - fractions (4 - 5) and the compounds 3 - 4 - 5 and 7 showed high cytotoxic activities when compared to appropriate reference drug (doxorubicin) and IC50 values (the concentrations of drug required to produce 50% inhibition of cell growth) were calculated for the isolated compounds.
The third part of this work focused on evaluation of the in-vivo antitumor activity of the methanolic extract of A. fragrantissima (Forssk.) Sch. Bip. and its isolated compounds 3 - 4 - 5 and 7 using Ehrlich’s Ascites Carcinoma (EAC) model in mice. A. fragrantissima (Forssk.) Sch. Bip. extract and its isolated compounds reduced the tumor weight compared to EAC-Control group. In addition - the compounds 3 - 7 treatments produced a dose dependent reduction in tumor weight. Determination of serum tumor necrosis factor – alpha (TNF-α) level highlighted that A. fragrantissima (Forssk.) Sch. Bip. extract and its isolated compounds significantly reduced its serum level compared to the EAC-Control group - where 3 - 5 - 7 groups produced a significant reduction in serum level of TNF-α compared to all other groups. Furthermore - A. fragrantissima (Forssk.) Sch. Bip. extract and the isolated compounds significantly increased the total antioxidant capacity (TAC) compared to EAC-Control especially compound 7. The histopathological examination revealed that A. fragrantissima (Forssk.) Sch. Bip. extract and its isolated compounds produced a better differentiation of tumor cells - with reduced nuclear pleomorphism and better formed tubular structures especially with high dose indicating the induction of apoptotic mechanism.
Finally - an in silico study was performed as a step to elucidate the mechanism of the cytotoxic effect of the compounds isolated from A. fragrantissima (Forssk.) Sch. Bip - where the structure of cirsiliol (5) was docked into the active sites of the crystal structures of PI3K and Akt - two protein kinases that are significantly involved in prostate and breast cancer processes.
Key Words: Achillea fragrantissima (Forssk.) Sch. Bip - anticancer - Ehrlich’s Ascites Carcinoma - Docking.
Aim of work:
Flora of Egypt especially in Sinai Peninsula is rich and diverse with medicinal and aromatic plants as well as herbs and spices. These plants have been used by local people in folk medicine for curing human and animal illnesses. The plants of genus Achillea as a part of Sinai Peninsula flora were and still a rich source of valuable natural products for treatment of many diseases; therefore - this study was designed to fulfill:
1. Collection of the plant material from Sinai Peninsula in Egypt.
2. Bioactivity-guided fractionation to isolate active compounds using different chromatographic techniques.
3. Identification and structure elucidation of the isolated compounds - using 1D NMR - 2D NMR and DEPT measurements.
4. In vitro cytotoxic and in vivo antitumor evaluations of the methanolic extract of Achillea fragrantissima (Forssk.) Sch. Bip. and its isolated compounds.
pharmacognosy
تصفح الوعاء  

Thesis 2018.
Al-sharabi, Ibrahim Mohamed Ahmed Abdul Wahid.
615 علم الصيدلة والعلاج  
Solubility in the physiological fluids is one of the most important properties of a drug candidate. Poor aqueous solubility could affect absorption and pharmacological activity of drugs. Therefore - investigating different approaches to enhance solubility of poorly soluble drugs has been an essential element of pharmaceutical researches for decades.
The aim of this study was to employ some of the solubility enhancement techniques to formulate the drug into oral dosage forms containing solubilized forms of it - while exploring the effect of some formulation variables on the resulting dosage forms.
Pharmaceutics

Thesis 2012.
زيادة، مجدي رشدي تهامي رمضان.
227 *تفسير القرآن   227.3 التفاسير السنية  
القرآن - المفسرون
تصفح الوعاء  

Thesis 2010
SHAFIE,WAFAA WAHBA MOHAMED
633 المحاصيل الحقلية والنباتية  
Wafaa Wahba Mohamed Shafie: Analysis of Gene Action for Yield and Quality characteristics in Diallel Crosses of Sesame. Unpublished Ph.D. Thesis - Department of Agronomy - Faculty of Agriculture - Ain Shams University - 2010. br Eight sesame genotypes were crossed in a diallel mating design - excluding reciprocals - to produce 28 F1 hybrid seeds in 2004 season and the 36 entries (8 parents + 28 F1’ s) were evaluated for eleven traits in 2005 season. The eight genotypes were re-crossed in the same diallel pattern in 2005 season and the 36 entries were evaluated for the same traits in 2006 season aiming to study heterosis - combing abilities - types of gene action and heritability - as well as correlation and path coefficient analysis for earliness - yield attributes and oil and protein contents in both seasons. br The results indicated that the mean squares due to all 36 genotypes as well as mean squares due to parents and crosses were highly significant for all studied characters - i.e - days to flowering - height of first capsule - plant height - fruiting zone length - number of fruiting branches/pant - number of capsules/plant - capsule length - 1000-seed weight - seed yield/plant - oil and protein percentages in both seasons - revealing the presence of sufficient genetic variability in the studied genotypes. br Parents vs. crosses mean squares as an indication to average heterosis for all hybrids were significant in all traits. Significant desirable negative or positive heteosis relative to mid and better parents were observed in many crosses for all traits in both seasons. br Both general and specific combining ability mean squares were found to be highly significant for all studied traits in both seasons - indicating the importance of both additive and non-additive gene effects in the expression of the studied traits. The ratios of GCA/SCA variances were greater than unity for days to flowering in the first season and near unity in the 2nd - height of first capsule - plant height - fruiting zone length - no. of fruiting branches - no. of capsules/plant - capsule length - 1000-seed weight - seed yield/plant - oil % and protein % in both seasons - indicating that the inheritance of these traits were mainly controlled by additive gene effects. However - ratios were less than unity for no. of capsules/plant in both seasons illustrating that this traits was mainly controlled by the non-additive gene effects. Good general combiner parents were identified for each of the studied traits. Some crosses exhibited significant desirable SCA effects in all studied traits and some of them involved at least one good general combiner parent - therefore - considered as promising F1 cross combinations for improving sesame traits. br High estimates of heritability values in the narrow sense exceeding 50% were detected for plant height - number of branches/plant - fruiting zone length - oil% and protein% in the two seasons. These values ranged -#102;-#114;-#111;-#109; 50.04% for number of branches/plant in 2005 season to 66.04% for oil % in 2006 season - indicating the importance of additive and additive x additive gene effects in the inheritance of these traits and consequently the effectiveness of selection for improving such traits in early segregating generations. However - moderate values of heritability in the narrow sense were obtained in both seasons for number of capsules/plant - capsule length - 1000-seed weight and seed yield/plant - ranging -#102;-#114;-#111;-#109; 32.67% for 1000-seed weight in the 1st season to 45.63% for seed yield/plant in the 2nd. With regard to the two earliness traits - i.e. days to flowering and height of first capsule - low estimates of narrow sense heritability were obtained in both seasons ranging -#102;-#114;-#111;-#109; 21.24% for days to flowering in the 2nd season to 27.49% for height of first capsule in the 2nd season - indicating that - in the case of moderate and low heritabilities in the narrow sense - response to selection for these traits in later segregating generations would be expected. br Except for oil% - the other 10 earliness - yield attributes and protein content exhibited consistent high estimates of broad sense heritabilities as compared to their respective narrow sense values ranging -#102;-#114;-#111;-#109; 84.6% for 1000-seed weight in 2005 season to 99.4% for height of first capsule in both seasons - indicating that dominance effects had prominent role in the inheritance of these traits. br Path analysis indicated that - plant height - fruiting zone length - height of first capsule and no. of capsules/plant and their interactions a crosse as the main sources of seed yield variation br . br Key Words: Sesame - Diallel crosses - Combining abilities - Heritability - Earliness - Yield - Oil - Protein - Correlation and path analysis. br Heterosis estimates - Wafaa Wahba Mohamed Shafie: Analysis of Gene Action for Yield and Quality Characteristics in Diallel Crosses of Sesame. Unpublished Ph.D. Thesis - Department of Agronomy - Faculty of Agriculture - Ain Shams University - 2010.
Eight sesame genotypes were crossed in a diallel mating design - excluding reciprocals - to produce 28 F1 hybrid seeds in 2004 season and the 36 entries (8 parents + 28 F1’ s) were evaluated for eleven traits in 2005 season. The eight genotypes were re-crossed in the same diallel pattern in 2005 season and the 36 entries were evaluated for the same traits in 2006 season aiming to study heterosis - combing abilities - types of gene action and heritability - as well as correlation and path coefficient analysis for earliness - yield attributes and oil and protein contents in both seasons.
The results indicated that the mean squares due to all 36 genotypes as well as mean squares due to parents and crosses were highly significant for all studied characters - i.e - days to flowering - height of first capsule - plant height - fruiting zone length - number of fruiting branches/pant - number of capsules/plant - capsule length - 1000-seed weight - seed yield/plant - oil and protein percentages in both seasons - revealing the presence of sufficient genetic variability in the studied genotypes.
Parents vs. crosses mean squares as an indication to average heterosis for all hybrids were significant in all traits. Significant desirable negative or positive heteosis relative to mid and better parents were observed in many crosses for all traits in both seasons.
Both general and specific combining ability mean squares were found to be highly significant for all studied traits in both seasons - indicating the importance of both additive and non-additive gene effects in the expression of the studied traits. The ratios of GCA/SCA variances were greater than unity for days to flowering in the first season and near unity in the 2nd - height of first capsule - plant height - fruiting zone length - no. of fruiting branches - no. of capsules/plant - capsule length - 1000-seed weight - seed yield/plant - oil % and protein % in both seasons - indicating that the inheritance of these traits were mainly controlled by additive gene effects. However - ratios were less than unity for no. of capsules/plant in both seasons illustrating that this traits was mainly controlled by the non-additive gene effects. Good general combiner parents were identified for each of the studied traits. Some crosses exhibited significant desirable SCA effects in all studied traits and some of them involved at least one good general combiner parent - therefore - considered as promising F1 cross combinations for improving sesame traits.
High estimates of heritability values in the narrow sense exceeding 50% were detected for plant height - number of branches/plant - fruiting zone length - oil% and protein% in the two seasons. These values ranged from 50.04% for number of branches/plant in 2005 season to 66.04% for oil % in 2006 season - indicating the importance of additive and additive x additive gene effects in the inheritance of these traits and consequently the effectiveness of selection for improving such traits in early segregating generations. However - moderate values of heritability in the narrow sense were obtained in both seasons for number of capsules/plant - capsule length - 1000-seed weight and seed yield/plant - ranging from 32.67% for 1000-seed weight in the 1st season to 45.63% for seed yield/plant in the 2nd. With regard to the two earliness traits - i.e. days to flowering and height of first capsule - low estimates of narrow sense heritability were obtained in both seasons ranging from 21.24% for days to flowering in the 2nd season to 27.49% for height of first capsule in the 2nd season - indicating that - in the case of moderate and low heritabilities in the narrow sense - response to selection for these traits in later segregating generations would be expected.
Except for oil% - the other 10 earliness - yield attributes and protein content exhibited consistent high estimates of broad sense heritabilities as compared to their respective narrow sense values ranging from 84.6% for 1000-seed weight in 2005 season to 99.4% for height of first capsule in both seasons - indicating that dominance effects had prominent role in the inheritance of these traits.
Path analysis indicated that - plant height - fruiting zone length - height of first capsule and no. of capsules/plant and their interactions a crosse as the main sources of seed yield variation
.
Key Words: Sesame - Diallel crosses - Combining abilities - Heritability - Earliness - Yield - Oil - Protein - Correlation and path analysis.
Heterosis estimates
تصفح الوعاء  

Thesis 2008 .
Mohamed, Mona Abou Eleaz.
658 إدارة الأعمال العامة   658.5 إدارة الإنتاج و الجودة   658.56 ضبط الإنتاج و الجودة   658.562 المواصفات و القياسات  
Total quality management (TQM) is a foundation for continual improvement although it is just one of several current paradigms in modern management. TQM had been originated in the manufacturing industry in Japan and USA and achieved well known and advertised success. TQM begins with understanding the needs of the customers. These needs are translated back into the work of the organization - that is - the tasks or processes by which the organization creates value for its customers. The processes of the organization are in turn closely aligned and linked with their suppliers - and these suppliers are treated as an integral part of the organization. The entire value-creating chain from supplier to customer is managed and continually improved to be ever more efficient in resource consumption and maximally effective in creating value for customers.
The main objective of this thesis is to present and demonstrate a comprehensive framework that enables management to choose the suitable one or more TQM methods for the application purpose. Choosing a TQM method mainly depends on the activity type (industry - enterprise - etc.) - age and size of organization - and managers’ perceptions of TQM. As shown later - this task isn’t that easy one because of the vast and interacted factors that bound the process.
This thesis studies the TQM from the view of the performances of existing TQM methods. First - it explains the necessary contents of quality such as quality definitions - quality dimensions - quality measurements - quality costs - and basic quality tools. Then the popular TQM methods such as Juran - Deming - and Crosby methods have been discussed. The criteria that affect the quality in general have been extracted after carrying out a comprehensive analysis of such TQM methods - TQM practices - and the relationships between both. Two multicriteria decision methods - AHP and ANP - are discussed. Both methods are the most prominent in use for performance measurement. Therefore - this thesis proposes AHP and ANP for measuring performances of TQM methods. A hierarchy for the TQM criteria and TQM methods is constructed based on the AHP principles.
For demonstration of the presented model - four TQM methods are nominated—Juran - Deming - Crosby - and Taguchi methods. The required hierarchy is constructed by feeding the necessary information of factors’ relationships into the commercial software “Expert Choice” which was developed to facilitate using the AHP method. Furthermore - different future
Mona Abou Eleaz Mohamed, ,Fac.of Eng.Dep.of Production Engineering.
تصفح الوعاء  

Thesis 2002 .
Mahmoud, Eman Mahmoud Ezzat
Ain Shams University. faculty of Medicine. Internal Medicine Department,

Thesis 2004 .
BADWEE, HAYAM MOHAMED SAID MAHMOUD
Ain Shams University. faculty of Agriculture. Agricultural Science Department,

Thesis 2007 .
Barhoma, Ahmed Gamal
Cairo University. Faculty of Medicine. Ophthalmology Department,

 







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