|
[9000450.] رقم البحث : 9000450 - |
|
Garlic improves altered vascular reactivity and plasma lipids in high cholesterol-fed rats / |
| |
قطاع الدراسات الطبية / الفسيولوجىا الإكلينكيه |
| تخصص البحث : الفسيولوجىا الإكلينكيه |
| |
Menoufia Medical Journal / / Vol. 25, No. 2 - July 2012 |
| |
ط/سالى سعيد على دنيا |
| |
endothelial dysfunction, garlic, hypercholesterolemia |
| |
Objective
The aim of this work was to study the effect of garlic on the lipid profile
of hypercholesterolemic rats and investigate the vascular reactivity to norepinephrine
and acetylcholine in hypercholesterolemic rats treated with garlic in-vitro experiments.
Background
Hypercholesterolemia is considered an important risk factor for the development
of atherosclerosis; currently, there is a major trend to use herbal remedies for the
treatment and prevention of hypercholesterolemia and garlic is used for this purpose.
Methods
Forty male rats were divided into the following four groups of 10 animals each:
(i) normal diet-fed animals (control), (ii) hypercholesterolemic animals,
(iii) hypercholesterolemic garlic-treated animals, and (iv) hypercholesterolemic
garlic-prophylactic animals. The animals were fed a standard food preparation
enriched with 2% cholesterol for 2 months and soya bean oil. Thirty days after
beginning the experiment, garlic was administered in the hypercholesterolemic
garlic-treated group whereas in the hypercholesterolemic garlic-prophylactic group
garlic was administered from the start till the end of the experiment. At the end of the
experiment, a blood sample was drawn from each rat to determine total cholesterol and
to separate the lipoproteins; also, a segment of the thoracic aorta was removed
to study endothelial function (vascular reactivity).
Results
Garlic reduced the total serum cholesterol levels and low-density lipoprotein-cholesterol
levels significantly. Endothelium-dependent relaxation was significantly greater in the
treated and prophylactic group compared with that in the hypercholesterolemic group.
Conclusion
Garlic played a significant role in prophylaxis and treatment of hypercholesterolemia
and improvement of endothelial dysfunction. |
| |
 Download Paper |
تسجيل دخول 
