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[9000447.] رقم البحث : 9000447 - |
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Fibroblast growth factor 23 as a risk factor of left ventricular hypertrophy and vascular calcification in predialysis chronic kidney disease patients / |
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قطاع الدراسات الطبية / الباطنه العامه |
| تخصص البحث : الباطنه العامه |
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Menoufia Medical Journal / / Vol. 25, No. 2 - July 2012 |
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أ/ حسن عبدالهادى أحمد عطية ( 105245473 ) |
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abdominal aortic calcification, chronic kidney disease, fibroblast growth factor 23,
left ventricular hypertrophy, left ventricular mass index |
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Objective
The objective of this study was to evaluate the possible role of fibroblast growth factor
23 (FGF23) in the occurrence of left ventricular hypertrophy and vascular calcification
in predialysis chronic kidney disease (CKD) patients.
Background
FGF23 is a suggested risk factor for poor outcome of CKD. This raises the possibility
that FGF23 is a hormone that controls calcium–phosphorus metabolism and is a real
risk factor for cardiovascular mortality and morbidity in predialysis CKD patients.
Materials and methods
Thirty predialysis CKD patients with estimated glomerular filtration rate
(90ZeGFR415 ml/min/1.73m2) by the modification of diet in renal diseases formula
were included in this study. Patients were recruited from the Internal Medicine
Department, Menoufia University (Egypt). Our controls were 10 individuals with
preserved kidney function of more than 90 ml/min/1.73m2 with normal BUN and
creatinine matched by age and sex. Routine and specific investigations (serum FGF23
measurement using ELISA immunoassay, serum intact parathyroid hormone,
conventional echocardiography, and lateral abdominal aortic radiograph for
calcification) were performed.
Results
The mean logFGF23 level in CKD patients was 2.3 ± 0.6 Ru/ml and was significantly
higher than that of control participants, 1.7 ± 0.1 Ru/ml (Po0.001). There was a
significant difference between CKD2–3 stage and CKD4 stage in the FGF23
(Po0.05) level but not in serum phosphorus (P40.05). Left ventricular mass index
was correlated positively with logFGF23 (r= 0.44, Po0.05) and negatively with
eGFR (r= – 0.4, Po0.05). Abdominal aortic calcification was correlated positively
with age (r =0.55, Po0.001), but had no correlation with FGF23 (r= 0.36, P40.05).
Conclusion
FGF23 could be an early risk factor for the occurrence of left ventricular hypertrophy
even before an increase in serum phosphorus in predialysis CKD patients. |
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