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Menoufia Medical Journal /
 Menoufia Medical Journal /
  تفاصيل البحث
 
[9000446.] رقم البحث : 9000446 -
PASD1 gene expression in acute myeloid leukemia patients /
  قطاع الدراسات الطبية / الباثولوجىه الإكلينكيه
تخصص البحث : الباثولوجىه الإكلينكيه
  Menoufia Medical Journal / / Vol. 25, No. 2 - July 2012
  د/ إيناس سعيد سيد أحمد محمد عيسى ( Enas_said_essa@yahoo.com - 106795544 )
  acute myeloid leukemia, cancer-testis antigens genes, PASD1
  Objective
To detect the expression of the PASD1 gene in acute myeloid leukemia (AML) patients
and its relation to clinical features and complete remission of AML.
Background
AML is a heterogeneous disease with variable clinical outcomes. PASD1 [Per ARNT
Sim (PAS) Domain containing protein 1] can stimulate autologous T-cell responses,
and it is therefore considered to be a potential immunotherapeutic target for the
treatment of various malignancies, including AML.
Materials and methods
The study was carried out on 60 AML patients (group I) and 30 healthy controls
(group II). Reverse transcriptase PCR analysis of the PASD1 gene was carried out for
all patients and controls.
Results
PASD1 was expressed in 12 (20%) AML patients, but was not expressed in any of the
30 controls. PASD1 expression was associated more with patients below 45 years
(66.7% of the PASD1-positive patients were <45 years old compared with 29.2% of
the PASD1-negative patients). No significant correlation was found between PASD1
gene positivity and any of the clinical and hematological variables of AML, except for
less incidence of fever at presentation. PASD1-positive patients achieved more
complete remission (66.7%) compared with PASD1-negative patients (35.4%)
(Po0.05).
Conclusion
PASD1 is an attractive leukemia-associated antigen. Its expression was associated
with young age and favorable outcome. However, further studies are required, with
standardization of the age, clinical, and cytogenetic and molecular genetic prognostic
markers, to confirm the prognostic value of PASD1 gene expression in AML, to assess
its correlation with clinical features of AML patients, and to investigate its role in
minimal residual disease detection and immunotherapy of AML.
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