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[9000445.] رقم البحث : 9000445 - |
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HEPATOPROTECTIVE EFFECTS OF METFORMIN ON FRUCTOSE INDUCED NON-ALCOHOLICSTEATOHEPATITIS IN RATS / |
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قطاع الدراسات الطبية / الصيدليه السريريه |
| تخصص البحث : الصيدليه السريريه |
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Menoufia Medical Journal / / Vol. 25, No. 2 - July 2012 |
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ط/ محمد فاروق احمد سيد احمد |
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metformin - insulin resistance - nonalcoholic steatohepatitis |
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The most known risk factor for nonalcoholic fatty liver disease (NAFLD) is the
metabolic syndrome. In this study, we characterized changes in liver
pathology, hepatic lipid composition, and plasma biochemistry occurring in
rats given fructose-enriched diet 10% (FED). Rats were given FED or
standard rat chow for 5 weeks. Rats on FED were divided into 2 groups: One
group of rats was fed FED only for 5 weeks and another group of rats was
received metformin 50 mg/kg for the last 2 weeks (2 weeks FED + 3 weeks
FED and metformin). FED rats had developed hepatic macrovesicular and
microvesicular fat deposits, with increase in hepatic triglycerides (+198%) and
hepatic cholesterol (+89%), but a decrease in hepatic phospholipids (-36%),
hypertriglyceridemia (+223%), and hypertension (+15%) . Also, in FED rats
there was significant increase in serum cholesterol and serum glucose
(100.6±2.5 , 9.0±0.4 respectively) , and signifcant increase in hepatic MDA
and TNF-? (209.9± 43.9 , <12.5 respectively). Metformin reduced blood
pressure (-24%), serum triglycerides (-36%), hepatic triglycerides (-51%),
hepatic macrovesicular fat (-51%) and increased Hepatic phospholipids
(+37%). Also, signifcant decrease in hepatic MDA and TNF-? (150.1± 27.0 ,
<10.5 respectively). In conclusion: Metformin could reduce most of
biochemical and tissue parameters and also improve the histopathological
features of liver asscociated with non alcoholic steatohepatitis in rats. |
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