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SECI Oncology Journal /
 SECI Oncology Journal /
  تفاصيل البحث
 
[9002055.] رقم البحث : 9002055 -
Hepatitis C Virus Load Kinetics and Clinical Outcome in Patients with Hematological Malignancies: Comparative Study of Autologous Bone Marrow Transplantation and Intensive Chemotherapy /
تخصص البحث : General
  SECI Oncology Journal / / vol.6 - 2018
  ندي طلعت فرغلي محمد
  اسامه - مؤلف رئيسي
  التهاب كبدي وبائي,اورام خبيثه,عظام
  It is estimated that over 170 million people suffer from HCV infection worldwide.1 The prevalence of HCV infection in patients with cancer ranges from 1.5% to 32.0%.2 chronic HCV infection in patients with cancer causes significant additional morbidity and mortality and can interfere with cancer treatment.3 Over the past two decades, considerable evidence has accumulated with regard to the association between HCV and several hematologic malignancies, most notably B-cell NHL.4
The natural course of HCV infection can be altered by cancer treatment. Previous studies have reported a high proportion of chemotherapy discontinuation among patients with cancer with HCV infection and hepatic flares. Damaged liver function after chemotherapy in HCV-infected patients may be related to immunosuppression and HCV reactivation. However, the mechanism of liver injury is still unclear. Poor outcomes may be attributed to hepatotoxicity in patients with underlying hepatitis C or worsening of hepatitis C because of increased HCV replication.5
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