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Menoufiya Medical Journal /
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  Menoufiya Medical Journal /
  
 

[9000439.] رقم البحث : 9000439 -
Effect of Pharyngeal Flap versus Palatal Lengthening Operation(Furlow) on Resonance Outcomes after Surgical Repair of Velopharyngeal Insufficiency /
  قطاع الدراسات الطبية / أنف وأذن
تخصص البحث : أنف وأذن
  Menoufiya Medical Journal / / Vol. 25, No. 2 - July 2012
  تاريخ تقديم البحث 04/12/2013
  تاريخ قبول البحث 04/12/2013
  عدد صفحات البحث 22
  د/ ياسر عبدالوهاب محمد خليل ( 106580804 )
  Furlow – pharyngeal flap – velopharyngeal insufficiency –
resonance- Speech outcome.
  Objective: This is a retrospective study comparing between Furlow and
Pharyngeal Flap techniques in treatment of velopharyngeal insufficiency
regarding complications and resonance outcomes (including hypernasality,
articulation errors, air emission, speech intelligibility).
Patients and Methods: Twenty eight patients were operated for correction of
velopharyngeal insufficiency between April 2010 and July 2012. Patients
fulfilled two criteria; velopharyngeal dysfunction unresponsive to speech
therapy and a moderate (40-50 percent) coronal gap on nasopharyngoscopy.
Sixteen patients were subjected to Furlow technique and twelve patients to
pharyngeal flap technique. All patients were evaluated preoperatively and 7
to 10 days post-operatively to evaluate the organic aspect then 2 to 6 months
postoperatively with perceptual speech analysis and flexible fiber-optic
nasopharyngoscopy. The patients were assessed for resonance rating to be
compared with preoperative one.
Results: Both Furlow and pharyngeal flap have a significant effect on
treatment of hypernasality. Pharyngeal flap has a significant effect on
management of pharyngalization of fricatives and facial grimace. Furlow has
a significant effect on treatment of regurgitation. No significant difference was
observed between Furlow and Pharyngeal flap techniques regarding
complications and resonance outcomes.
Conclusion: Pharyngeal flap technique and Furlow double opposing Z plasty
technique, both are effective in treatment of hypernasality and have no
significant difference in the postoperative resonance outcome and rate of
development of postoperative complications when used for management of
velopharyngeal insufficiency.
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[9000440.] رقم البحث : 9000440 -
Surgical outcomes for rhinogenic contact point headache. /
  قطاع الدراسات الطبية / أنف وأذن
تخصص البحث : أنف وأذن
  Menoufiya Medical Journal / / Vol. 25, No. 2 - July 2012
  تاريخ تقديم البحث 04/12/2013
  تاريخ قبول البحث 04/12/2013
  عدد صفحات البحث 12
  د/ ياسر عبدالوهاب محمد خليل ( 106580804 )
  Headache- Rhinogenic headache- Contact Headache
Patients and methods: This study included 30 patients with
rhinogenic headache for more than one year and diagnosed to have
sinonasal anatomical variations as deviated nasal septum and
concha bullosa. 5 cases were excluded from the study, these
patients refused surgery. 25 patients (83%) who their ages ranged
from 19 to 43 years were included in this study. 14 patients were
males (46%) and 11 were females (36%) were included in this study.
Results: multiple anatomical variations were noted by endoscopy and
CT scans in thirty patients. These variations included septum
deviation in 22 patients (88%) followed by concha bullosa in 11
patients (44%) then hypertrophied inferior turbinate in 5 patients
(20%). In these 25 patients, 21 cases (84%) showed complete cure,
while 4 cases (16%) showed improvement only.
Conclusion: Minor intranasal anatomical variations may be the cause
of primary headache misdiagnosed as a headache of unknown
etiology. The nasal surgeries in our study has succeeded in
eliminating or significantly reducing such headache attacks.
  Objective: this study aimed to investigate the role of some anatomical
variations in rhinogenic headache and to evaluate the role of surgery
in management of this headache.
Patients and methods: This study included 30 patients with
rhinogenic headache for more than one year and diagnosed to have
sinonasal anatomical variations as deviated nasal septum and
concha bullosa. 5 cases were excluded from the study, these
patients refused surgery. 25 patients (83%) who their ages ranged
from 19 to 43 years were included in this study. 14 patients were
males (46%) and 11 were females (36%) were included in this study.
Results: multiple anatomical variations were noted by endoscopy and
CT scans in thirty patients. These variations included septum
deviation in 22 patients (88%) followed by concha bullosa in 11
patients (44%) then hypertrophied inferior turbinate in 5 patients
(20%). In these 25 patients, 21 cases (84%) showed complete cure,
while 4 cases (16%) showed improvement only.
Conclusion: Minor intranasal anatomical variations may be the cause
of primary headache misdiagnosed as a headache of unknown
etiology. The nasal surgeries in our study has succeeded in
eliminating or significantly reducing such headache attacks.
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[9000441.] رقم البحث : 9000441 -
HISTOLOGICAL, IMMUNOHISTOCHEMICAL AND BIOCHEMICAL /
  قطاع الدراسات الطبية / الصيدليه السريريه
تخصص البحث : الصيدليه السريريه
  Menoufiya Medical Journal / / Vol. 25, No. 2 - July 2012
  تاريخ تقديم البحث 04/12/2013
  تاريخ قبول البحث 04/12/2013
  عدد صفحات البحث 14
  محمـد أحمد عبد الفتاح عطية المهدى
  Clinical Pharmacology, Biochemistry and Histology
  Background: Diabetes mellitus and its complication have reached epidemic proportions
worldwide. Exenatide is one of glucagon -like peptide-1 (GLP-1) receptor agonists. It is
the synthetically derived peptide of exendin-4. It has been shown to improve glycemic
state in patients with type 2 diabetes. The aim of the work was to study the effect of
exenatide on islets of Langerhans of diabetic adult male rats based on histological,
immunohistochemical and biochemical study.Materials and Methods: 30 adult male
albino rats were divided into four groups; the 1st group was –ve control, the 2nd group was
given exenatide at a dose of 2 ,g/ kg twice daily by S.C route and served as +ve control.
The 3rd group was given streptozotocin (STZ) as a single dose of 60mg/ kg I.P to induce
diabetes. The 4th group was given exenatide, 4 days after administration of STZ. Blood
glucose level was estimated daily and after one week, serum glucagon- like peptide
(GLP-1) and insulin levels were also measured. Sections of pancreas were prepared and
stained with H&E, Masson trichrome and immunohistochemical staining of B- cells by
anti-insulin antibody. The density (area %) of anti-insulin antibody reaction and number of
B- cells were studied. Results of diabetic group (GIII) showed marked degenerative and
apoptotic changes of cells mostly in the centers of islets with insulinitis. Also deposition of
connective tissue around and in between islets cells was seen. Moreover, there was
reduction in area % of anti-insulin antibody reaction and number of B- cells. Biochemical
results showed elevation of blood glucose level, reduction of insulin level and non
significant change of GLP-1 level compared to control group (G1). Administration of
exenatide resulted in improvement of morphological picture of islets cells mainly of Bcells.
Moreover, the previously mentioned morphometric parameters detected significant
increase. There was lowering of blood glucose level, elevation of insulin level and non
significant change of GLP-1 Level. Conclusion: It is concluded that exenatide is effective
drug in reducing the degenerative changes of B- cells associated with diabetes mellitus.
This could be explained by the agonistic activity of exenatide on GLP-1 receptor
producing GLP-1 mimetic effects. Such effect makes this drug a beneficial drug to be
used in diabetic patients.
.
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[9000442.] رقم البحث : 9000442 -
HARMONIC SCALPEL TONSILLECTOMY VERSUS COBLATION TONSILLECTOMY /
  قطاع الدراسات الطبية / أنف وأذن
تخصص البحث : أنف وأذن
  Menoufiya Medical Journal / / Vol. 25, No. 2 - July 2012
  تاريخ تقديم البحث 04/12/2013
  تاريخ قبول البحث 04/12/2013
  عدد صفحات البحث 8
  Magdy A. Salama
  tonsillectomy; Harmonic scalpel, Coblation
  OBJECTIVES: To determine if there was a difference between harmonic scalpel
tonsillectomy and coblation tonsillectomy in terms of morbidity and operative time in
children. STUDY DESIGN AND SETTING: A prospective single-blind randomized
controlled trial comparing harmonic scalpel and coblation tonsillectomy in children aged
between 5 and 15 years who underwent tonsillectomy for recurrent acute tonsillitis.
RESULTS: One hundred and fifty children were included in this study. Patients
completed the pain and dietary scales. The average operative time was less in harmonic
scalpel tonsillectomy (P<0.05). The post-operative pain was lower in harmonic scalpel
group in the 1st, 2nd and 3rd post-operative days and it was found statistically significant (P
< 0.001, 002 and 0.012, respectively). The intra-operative blood loss was 2.40 ± 3.42 ml
for Harmonic scalpel and was 3.43± 3.42 ml (P>0.05, not significant). Similar rates of
nausea and vomiting were detected among our patients.
CONCLUSION: We can conclude that the harmonic scalpel instrument is safe, very effective,
with minimal intra-operative blood loss and with less post-operative pain. So, the use of the
harmonic scalpel for tonsillectomy may have several advantages over standard methods and
coblation tonsillectomy.
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[9000443.] رقم البحث : 9000443 -
SENTINEL LYMPH NODE IDENTIFICATIONS IN PAPILLARY THYROID CANCER. /
  قطاع الدراسات الطبية / أنف وأذن
تخصص البحث : أنف وأذن
  Menoufiya Medical Journal / / Vol. 25, No. 2 - July 2012
  تاريخ تقديم البحث 04/12/2013
  تاريخ قبول البحث 04/12/2013
  عدد صفحات البحث 12
  د/ عصام عبدالونيس بحيرى ( 122160184 )
  CLND, Otolaryngology
  Background:- Cervical lymph node metastases are very common in
patients with papillary thyroid cancer (PTC). The sentinel lymph node
(SLN) is defined as the first draining lymph node in the lymphatic
basin into which the primary tumor drains. The pathological status of
SLN actually reflects the histology of the remaining regional
lymphatic and extension of the primary tumor and so presence or
absence of the SLN determines whether neck dissection of the
regional lymphatic is indicated or not. Also neck dissection in patients
with papillary thyroid carcinoma (PTC) is a matter of controversy
because it depends mainly on expectation not actual lymphatic
spread of the tumor. although PTC has an excellent prognosis,
lymphatic spread is associated with increased risk of loco-regional
recurrence, which significantly impairs quality-of-life and can alter
prognosis of the patient. Therefore, the identification of lymph node
metastases preoperatively is very important for the surgeon to plan
the optimal surgical therapy for the individual patient. also study of
SLN in patients with PTC is true and recent advance in the
management of PTC.
Our aim is to study the feasibility of sentinel lymph node
identifications in patients with PTC and its influence in modifying the
surgical management of lymph node metastases.
Patients & methods - Over the period from May 2010 to March 2013,
12 patients had PTC by FNAC were enrolled in this study .Metheline
blue dye was injected in the primary site of the thyroid tumor via
thyroidectomy approach with special precautions. After SLN
identification ,histopathological analysis were done included
microscopic examination and histological grading.
Results-from the 12 patient enrolled in the study, we were able to
identify sentinel lymph node in 10/12 cases (83.3%).with true + VE
7/12 and true – VE1/12 the mean number of sentinel lymph nodes
were 2 (range 1-3).The histopathological study reveals 7/12 true
positive patients with cancer cells in the SLN obtained and only 1/12
true negative patients with no cancer cells in in the SLN obtained
,there is 3/12 false +ve and 1/12 false negative patients.
micrometastases was detected in 7/12 patients and occult
micrometastases was detected in3/12 patients.
Conclusions- This study showed that SLN was feasible, repeatable
and accurate and reduced false negative rates and increased
detection rates of lateral neck sentinel lymph nodes. The main value
of sentinel lymph node identification is to avoid unnecessary neck
dissection It helps to select patients for compartment neck dissection
to avoid unnecessary neck dissection and possible morbidity. also it
helps to select patients indicated or not indicated for ablative I 131
with accuracy. it helps to identify lymph node drainage outside the
central compartment with appropriate approach and extent of
surgery. Also it is cheap, easy ,safe, and can be performed in the
same site and time of the procedures planned. Further well designed
randomized studies are necessary to validate and further optimize
the SLN identification in patients with PTC.
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[9000444.] رقم البحث : 9000444 -
Usual ocular presentations as unusual paranasal Sinus presentations /
  قطاع الدراسات الطبية / أنف وأذن
تخصص البحث : أنف وأذن
  Menoufiya Medical Journal / / Vol. 25, No. 2 - July 2012
  تاريخ تقديم البحث 04/12/2013
  تاريخ قبول البحث 04/12/2013
  عدد صفحات البحث 8
  د/ عصام عبدالونيس بحيرى ( 122160184 )
  Background:- Ocular manifestations without sinonasal symptoms can cause
perplexity and delayed presentations in patients with paranasal sinus
pathology. So the aim of this study was to study the value of ordinary ocular
complains in patients without typical paranasal sinus symptoms and to
discuss the possible mechanisms and prognosis of such patients.
Methods:- Retrospective study on 476 patient complaining from usual ocular
symptoms but ophthalmic examination were free referred for
otorhinolaryngology consultations, 31 patients (6.5%) selected had an
ophthalmic complains without ordinary sinonasal symptoms but with
pathology involving the paranasal sinuses discovered accidentally after
diagnostic nasal endoscopy and C.A.T to exclude paranasal sinus
disorders.Patients underwent symptoms anamnesis, ophthalmic and
otolaryngological examination including diagnostic nasal endoscopy and
computed tomography (CT) scan. Effect of treatment on patient symptoms
was also analyzed. RESULTS: Ocular symptoms and signs presentations
were orbital pain in all patients (100%); proptosis (n=8; 25.8%), blurred vision
(n=16;51.6%); impairment of ocular mobility (n=3, 9.6%); ptosis(n=1;3.2%)
and epiphoria (n=2;6.4%). Paranasal sinus pathology was observed on the
anterior group of sinuses (maxillary and or frontal and anterior ethmoids (n
=16; 51.6%), posterior group(sphenoid and /or posterior ethmoids (n=10,
32.2%), and both sides (n=5, 16.1%). Endoscopic sinus surgery were done
for all patients Ophthalmic complaints disappeared in (67.7%), improved in
(22.6%) with total success of (90%). Conclusion: with absence of usual
paranasal sinus symptoms, patients with orbital pain, proptosis and visual
acuity changes must be referred early for otorhinolaryngology consultations.
Visual acuity changes and direction of proptosis can direct attention to
paranasal sinuses involved (i.e. anterior or posterior).
  Otorhinolaryngology, (i.e. anterior or posterior).
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[9000445.] رقم البحث : 9000445 -
HEPATOPROTECTIVE EFFECTS OF METFORMIN ON FRUCTOSE INDUCED NON-ALCOHOLICSTEATOHEPATITIS IN RATS /
  قطاع الدراسات الطبية / الصيدليه السريريه
تخصص البحث : الصيدليه السريريه
  Menoufiya Medical Journal / / Vol. 25, No. 2 - July 2012
  تاريخ تقديم البحث 04/12/2013
  تاريخ قبول البحث 04/12/2013
  عدد صفحات البحث 16
  ط/ محمد فاروق احمد سيد احمد
  metformin - insulin resistance - nonalcoholic steatohepatitis
  The most known risk factor for nonalcoholic fatty liver disease (NAFLD) is the
metabolic syndrome. In this study, we characterized changes in liver
pathology, hepatic lipid composition, and plasma biochemistry occurring in
rats given fructose-enriched diet 10% (FED). Rats were given FED or
standard rat chow for 5 weeks. Rats on FED were divided into 2 groups: One
group of rats was fed FED only for 5 weeks and another group of rats was
received metformin 50 mg/kg for the last 2 weeks (2 weeks FED + 3 weeks
FED and metformin). FED rats had developed hepatic macrovesicular and
microvesicular fat deposits, with increase in hepatic triglycerides (+198%) and
hepatic cholesterol (+89%), but a decrease in hepatic phospholipids (-36%),
hypertriglyceridemia (+223%), and hypertension (+15%) . Also, in FED rats
there was significant increase in serum cholesterol and serum glucose
(100.6±2.5 , 9.0±0.4 respectively) , and signifcant increase in hepatic MDA
and TNF-? (209.9± 43.9 , <12.5 respectively). Metformin reduced blood
pressure (-24%), serum triglycerides (-36%), hepatic triglycerides (-51%),
hepatic macrovesicular fat (-51%) and increased Hepatic phospholipids
(+37%). Also, signifcant decrease in hepatic MDA and TNF-? (150.1± 27.0 ,
<10.5 respectively). In conclusion: Metformin could reduce most of
biochemical and tissue parameters and also improve the histopathological
features of liver asscociated with non alcoholic steatohepatitis in rats.
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[9000446.] رقم البحث : 9000446 -
PASD1 gene expression in acute myeloid leukemia patients /
  قطاع الدراسات الطبية / الباثولوجىه الإكلينكيه
تخصص البحث : الباثولوجىه الإكلينكيه
  Menoufiya Medical Journal / / Vol. 25, No. 2 - July 2012
  تاريخ تقديم البحث 04/12/2013
  تاريخ قبول البحث 04/12/2013
  عدد صفحات البحث 6
  د/ إيناس سعيد سيد أحمد محمد عيسى ( Enas_said_essa@yahoo.com - 106795544 )
  acute myeloid leukemia, cancer-testis antigens genes, PASD1
  Objective
To detect the expression of the PASD1 gene in acute myeloid leukemia (AML) patients
and its relation to clinical features and complete remission of AML.
Background
AML is a heterogeneous disease with variable clinical outcomes. PASD1 [Per ARNT
Sim (PAS) Domain containing protein 1] can stimulate autologous T-cell responses,
and it is therefore considered to be a potential immunotherapeutic target for the
treatment of various malignancies, including AML.
Materials and methods
The study was carried out on 60 AML patients (group I) and 30 healthy controls
(group II). Reverse transcriptase PCR analysis of the PASD1 gene was carried out for
all patients and controls.
Results
PASD1 was expressed in 12 (20%) AML patients, but was not expressed in any of the
30 controls. PASD1 expression was associated more with patients below 45 years
(66.7% of the PASD1-positive patients were <45 years old compared with 29.2% of
the PASD1-negative patients). No significant correlation was found between PASD1
gene positivity and any of the clinical and hematological variables of AML, except for
less incidence of fever at presentation. PASD1-positive patients achieved more
complete remission (66.7%) compared with PASD1-negative patients (35.4%)
(Po0.05).
Conclusion
PASD1 is an attractive leukemia-associated antigen. Its expression was associated
with young age and favorable outcome. However, further studies are required, with
standardization of the age, clinical, and cytogenetic and molecular genetic prognostic
markers, to confirm the prognostic value of PASD1 gene expression in AML, to assess
its correlation with clinical features of AML patients, and to investigate its role in
minimal residual disease detection and immunotherapy of AML.
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[9000447.] رقم البحث : 9000447 -
Fibroblast growth factor 23 as a risk factor of left ventricular hypertrophy and vascular calcification in predialysis chronic kidney disease patients /
  قطاع الدراسات الطبية / الباطنه العامه
تخصص البحث : الباطنه العامه
  Menoufiya Medical Journal / / Vol. 25, No. 2 - July 2012
  تاريخ تقديم البحث 04/12/2013
  تاريخ قبول البحث 04/12/2013
  عدد صفحات البحث 11
  أ/ حسن عبدالهادى أحمد عطية ( 105245473 )
  abdominal aortic calcification, chronic kidney disease, fibroblast growth factor 23,
left ventricular hypertrophy, left ventricular mass index
  Objective
The objective of this study was to evaluate the possible role of fibroblast growth factor
23 (FGF23) in the occurrence of left ventricular hypertrophy and vascular calcification
in predialysis chronic kidney disease (CKD) patients.
Background
FGF23 is a suggested risk factor for poor outcome of CKD. This raises the possibility
that FGF23 is a hormone that controls calcium–phosphorus metabolism and is a real
risk factor for cardiovascular mortality and morbidity in predialysis CKD patients.
Materials and methods
Thirty predialysis CKD patients with estimated glomerular filtration rate
(90ZeGFR415 ml/min/1.73m2) by the modification of diet in renal diseases formula
were included in this study. Patients were recruited from the Internal Medicine
Department, Menoufia University (Egypt). Our controls were 10 individuals with
preserved kidney function of more than 90 ml/min/1.73m2 with normal BUN and
creatinine matched by age and sex. Routine and specific investigations (serum FGF23
measurement using ELISA immunoassay, serum intact parathyroid hormone,
conventional echocardiography, and lateral abdominal aortic radiograph for
calcification) were performed.
Results
The mean logFGF23 level in CKD patients was 2.3 ± 0.6 Ru/ml and was significantly
higher than that of control participants, 1.7 ± 0.1 Ru/ml (Po0.001). There was a
significant difference between CKD2–3 stage and CKD4 stage in the FGF23
(Po0.05) level but not in serum phosphorus (P40.05). Left ventricular mass index
was correlated positively with logFGF23 (r= 0.44, Po0.05) and negatively with
eGFR (r= – 0.4, Po0.05). Abdominal aortic calcification was correlated positively
with age (r =0.55, Po0.001), but had no correlation with FGF23 (r= 0.36, P40.05).
Conclusion
FGF23 could be an early risk factor for the occurrence of left ventricular hypertrophy
even before an increase in serum phosphorus in predialysis CKD patients.
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[9000448.] رقم البحث : 9000448 -
The role of microalbuminuria in population screening for chronic kidney disease in an Egyptian village chronic kidney disease in an Egyptian village /
  قطاع الدراسات الطبية / صحه المجتمع والصحه العامه
تخصص البحث : صحه المجتمع والصحه العامه
  Menoufiya Medical Journal / / Vol. 25, No. 2 - July 2012
  تاريخ تقديم البحث 04/12/2013
  تاريخ قبول البحث 17/12/2013
  عدد صفحات البحث 5
  ربيع الدسوقى البهنســى
  chronic kidney disease, diabetes mellitus, early detection, hypertension,
microalbuminuria, prevalence, screening
  Objectives
The study aimed at determining the prevalence of and risk factors for chronic kidney
disease (CKD) using microalbuminuria (MA) as a screening test in a rural area in
Gharbia Governorate.
Background
CKD is being increasingly recognized as a public health problem. There is still paucity
of data on the prevalence of and risk factors for CKD by using MA as a screening test
in the Middle East.
Methods
A randomly chosen sample of 320 apparently healthy individuals were interviewed in
Shennera village in Gharbia Governorate using a structured questionnaire including
information about risk factors for MA. They were also subjected to laboratory
investigations including analyses of microalbumin, creatinine, and random blood sugar
levels and lipid profile.
Results
The mean age of the studied sample was 35.7± 13.7 years; 50.9% were male.
Only 85% of the sample had sufficient income. The prevalence of MA was 14.4%.
The prevalence of CKD (estimated glomerular filtration rateo60 ml/min/1.73m2+ MA)
was 15.6%, but those with elevated creatinine levels comprised 2.8% of the studied
group. MA showed an increasing trend with age. The prevalence of MA was
significantly higher among diabetic patients, hypertensive patients, obese individuals,
cardiovascular disease patients, and smokers. The independent predictor variables
associated with the presence of MA in a mutually adjusted logistic regression
model were diabetes (odds ratio = 8.62, 95% confidence interval: 2.62–28.31)
and hypertension (odds ratio= 4.92, 95% confidence interval: 1.63–14.86).
Conclusion
Screening of MA seemed to be an easy, equally, or even more efficient method for
early identification of significant numbers of individuals with CKD compared with other
conventional methods, particularly among those with uncontrolled or undetected
diseases such as diabetes or hypertension.
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[9000449.] رقم البحث : 9000449 -
Prevalence of depression, anxiety, and obsessive–compulsive disorders among secondary school students in Menoufia Governorate, Egypt /
  قطاع الدراسات الطبية / صحه المجتمع والصحه العامه
تخصص البحث : صحه المجتمع والصحه العامه
  Menoufiya Medical Journal / / Vol. 25, No. 2 - July 2012
  تاريخ تقديم البحث 04/12/2013
  تاريخ قبول البحث 17/12/2013
  عدد صفحات البحث 5
  ربيع الدسوقى البهنســى
  anxiety, depression, epidemiology, obsessive–compulsive disorder, secondary school
students
  Objectives
The aim of this study was to estimate the prevalence of depression, anxiety,
and obsessive–compulsive disorders among secondary school students and to assess
the comorbidities of these disorders.
Background
Any type of mental illness can have a negative impact on cognitive development and
learning and involves a very high cost to both the individual and society. Anxiety and
depression can be considered reliable indicators for the assessment of mental illness
in a community.
Participants and methods
from a total of 83 635 secondary school students in Menoufia Governorate during the
academic year 2010–2011, using a multistage random sampling technique, a sample
of 1373 students was selected and surveyed from March 2011 to April 2012 by
means of the Beck Depression Inventory, 2nd ed., the Costello–Comrey Anxiety Scale,
and the Obsessive–Compulsive Disorder Scale, all of which were answered by the
participants. Those with scores higher than the cutoff values were interviewed by a
psychiatrist for the final clinical diagnosis on the basis of the Diagnostic and Statistical
Manual of Mental Disorders, 4th ed. criteria.
Results
The prevalence of depressive symptoms was 21.5% for mild, 7.1% for moderate,
and 0% for severe depression in this study group. The total prevalence of depressive
symptoms was 28.6%, and the prevalence of depressive disorders was 11.3%.
The prevalence of anxiety symptoms was 41.2% and that for anxiety disorders was
21%. The prevalence of obsessive–compulsive symptoms was 15.8% and that
of obsessive–compulsive disorder was 2.7%. Comorbidities of mental disorders were
common.
Conclusion
According to these findings, the high rate of mental disorders among adolescents
in our community calls for more attention from the family and educational and health
institutes. Comorbidities associated with mental disorders are common. In addition,
assessment using screening is recommended.
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[9000450.] رقم البحث : 9000450 -
Garlic improves altered vascular reactivity and plasma lipids in high cholesterol-fed rats /
  قطاع الدراسات الطبية / الفسيولوجىا الإكلينكيه
تخصص البحث : الفسيولوجىا الإكلينكيه
  Menoufiya Medical Journal / / Vol. 25, No. 2 - July 2012
  تاريخ تقديم البحث 04/12/2013
  تاريخ قبول البحث 17/12/2013
  عدد صفحات البحث 9
  ط/سالى سعيد على دنيا
  endothelial dysfunction, garlic, hypercholesterolemia
  Objective
The aim of this work was to study the effect of garlic on the lipid profile
of hypercholesterolemic rats and investigate the vascular reactivity to norepinephrine
and acetylcholine in hypercholesterolemic rats treated with garlic in-vitro experiments.
Background
Hypercholesterolemia is considered an important risk factor for the development
of atherosclerosis; currently, there is a major trend to use herbal remedies for the
treatment and prevention of hypercholesterolemia and garlic is used for this purpose.
Methods
Forty male rats were divided into the following four groups of 10 animals each:
(i) normal diet-fed animals (control), (ii) hypercholesterolemic animals,
(iii) hypercholesterolemic garlic-treated animals, and (iv) hypercholesterolemic
garlic-prophylactic animals. The animals were fed a standard food preparation
enriched with 2% cholesterol for 2 months and soya bean oil. Thirty days after
beginning the experiment, garlic was administered in the hypercholesterolemic
garlic-treated group whereas in the hypercholesterolemic garlic-prophylactic group
garlic was administered from the start till the end of the experiment. At the end of the
experiment, a blood sample was drawn from each rat to determine total cholesterol and
to separate the lipoproteins; also, a segment of the thoracic aorta was removed
to study endothelial function (vascular reactivity).
Results
Garlic reduced the total serum cholesterol levels and low-density lipoprotein-cholesterol
levels significantly. Endothelium-dependent relaxation was significantly greater in the
treated and prophylactic group compared with that in the hypercholesterolemic group.
Conclusion
Garlic played a significant role in prophylaxis and treatment of hypercholesterolemia
and improvement of endothelial dysfunction.
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[9000451.] رقم البحث : 9000451 -
Infection in diabetic foot /
  قطاع الدراسات الطبية / جراحه العامه
تخصص البحث : جراحه العامه
  Menoufiya Medical Journal / / Vol. 25, No. 2 - July 2012
  تاريخ تقديم البحث 04/12/2013
  تاريخ قبول البحث 17/12/2013
  عدد صفحات البحث 5
  أ/ سعيد ابراهيم الملاح ( smallah1@yahoo.com - 0122130947 )
  diabetic foot infection, multidrug-resistant organisms, polymicrobial, risk factors
  Objectives
The present study was carried out to determine the prevalence of aerobic and
anaerobic pathogens in diabetic foot infections (DFIs), detect their susceptibility
to different antimicrobial agents, investigate the microbiological profiles of DFIs in
relation to different grades of Wagner classification, and assess the risk factors
for DFIs.
Background
DFI is the most frequent reason for diabetes-related hospitalization. It develops
because of several diabetes-related factors including arterial insufficiency, neuropathy,
foot deformities, previous ulcers, previous amputation, and local trauma.
Materials and methods
The study was carried out on clinical specimens taken from 100 diabetic patients
(50 patients had type I insulin-dependent diabetes mellitus (IDDM) and 50 patients
had type II noninsulin-dependent diabetes mellitus (NIDDM) and 50 nondiabetic patients
with foot infection during the period from May 2011 to July 2012. The specimens
were cultured using aerobic and anaerobic microbiological techniques, and antibiotic
susceptibility testing was performed according to the methods recommended by the
Clinical and Laboratory Standards Institute (CLSI). Multidrug-resistant organisms were
detected including oxacillin-resistant and vancomycin-resistant staphylococci and
gram-negative bacilli extended-spectrum beta-lactamase producers.
Results
DFIs were polymicrobial in 76% of cases. Staphylococcus aureus was the most
common aerobic isolate (17.6%) (including 74.4% methicillin resistant and 23.1%
vancomycin resistant). Peptostreptococcus spp. were the most common anaerobic
isolate (39.4%). Extended-spectrum b-lactamase production was detected in 53.4%
of Gram-negative bacilli. About 62% of diabetic patients were infected with multidrugresistant
organisms. The risk factors for DFIs were duration of diabetes more than
1 year, random blood sugar of at least 200 mg/dl, trauma, previous ulcer and
amputation, and comorbidities related to diabetes.
Conclusion
Imipenem was the most effective drug against all isolates. Effective glycemic control
and educating patients on the prophylactic foot care are of key importance for
decreasing DFIs.
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[9000452.] رقم البحث : 9000452 -
Compliance of diabetic patients with the prescribed clinical regimen /
  قطاع الدراسات الطبية / صحه المجتمع والصحه العامه
تخصص البحث : صحه المجتمع والصحه العامه
  Menoufiya Medical Journal / / Vol. 25, No. 2 - July 2012
  تاريخ تقديم البحث 04/12/2013
  تاريخ قبول البحث 17/12/2013
  عدد صفحات البحث 4
  إيمان أحمد عطيه
  clinical regimen, compliance, diabetes mellitus
  Objectives
This study aimed at studying the prevalence of noncompliance among diabetic
patients in Gharbia governorate in Egypt as well its causes, its effect on glycemic
control, and factors affecting it.
Background
There is growing evidence suggesting that because of the alarmingly low rates of
compliance, increasing the effectiveness of compliance interventions may have a great
impact on the health of the population. Promotion of therapeutic compliance is
considered an integral component of patient care. It has been shown that despite
effective methods of treatment, many diabetic patients fail to achieve satisfactory
glycemic control, which leads to accelerated development of complications and
increased mortality.
Patients and methods
A total of 339 diabetic patients who fulfilled the inclusion criteria were recruited in
the present study. Compliance to treatment was evaluated during patients’ visits to
health units in Gharbia governorate. Medication compliance was assessed during
a personal interview with each patient using a multiple-choice questionnaire. Blood
samples were obtained for measurement of glycated hemoglobin (HbA1c).
Results
In the study population, the compliance rates were observed to be suboptimal. The
most important social factors that significantly affected compliance rates included age,
income, and educational level. Among the factors that significantly affected
compliance rates were duration of treatment, presence of diseases other than
diabetes, and the number of prescribed drugs. Another factor that played an important
role was diabetes care costs. The most common reasons for low rates of compliance
were forgetfulness and high cost of treatment.
Conclusion
An improvement in the compliance level may be achieved through improvement of
patients’ economic levels as well as reduction in the cost of medication. The number of
drugs and doses should be reduced as much as possible through continuous research
involving doctors and pharmaceutical companies.
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[9000453.] رقم البحث : 9000453 -
Neurobehavioral, respiratory, and auditory disorders among mercury-exposed fluorescent lamp workers /
  قطاع الدراسات الطبية / صحه المجتمع والصحه العامه
تخصص البحث : صحه المجتمع والصحه العامه
  Menoufiya Medical Journal / / Vol. 25, No. 2 - July 2012
  تاريخ تقديم البحث 04/12/2013
  تاريخ قبول البحث 17/12/2013
  عدد صفحات البحث 5
  جعفر محمد عبدالرسول
  audiometry, neurobehavioral test battery, occupational mercury exposure, spirometry
  Objective
The aim of this work was to study some of the health disorders resulting from
occupational exposure to mercury among workers in a fluorescent lamp factory.
Background
With the fast market growth of fluorescent lamps, the associated emissions and risk
of mercury, which is an essential component in all types of fluorescent lamps, have
received increasing public attention worldwide. Low doses of mercury exert toxicity
on various human organs, including the central nervous, renal, respiratory,
reproduction, immune, cardiovascular, skin, and motor systems.
Methods
A cross-sectional study was carried out on 138 workers in a fluorescent lamp factory
and a nonoccupationally exposed group of 151 individuals. An environmental study
of mercury and noise levels was carried out. Neurobehavioral tests, spirometric
measurements, and audiometric examination were performed. Urinary mercury level
was also measured for all participants.
Results
In the exposed group, the mean value of urinary mercury level (mg/g creatinine) was
significantly increased among those who showed behavioral changes and hearing loss
or had other manifestations related to mercury toxicity. With increasing duration
of employment in years or with increasing urinary mercury level, the performance of
neurobehavioral test battery and spirometric measurements deteriorated. Prominent
symptoms among mercury-exposed workers included tremors, emotional lability,
memory changes, neuromuscular changes, and performance deficits in tests of
cognitive and/or motor functions.
Conclusion
The neurobehavioral test battery must be used to study subclinical central nervous
system dysfunction because of mercury toxicity, especially to evaluate the severity
of the effects of mercury in epidemiological studies. This study also reinforces the need
for effective preventive programs at fluorescent lamp industry workplaces, especially
in developing countries with the most unhygienic ill-ventilated conditions.
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