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Menoufiya Medical Journal /
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  Menoufiya Medical Journal /
  
 

[9000435.] رقم البحث : 9000435 -
SONOGRAPHIC PARAMETERS PREDICTORS FOR /
  قطاع الدراسات الطبية / نساء وتوليد
تخصص البحث : نساء وتوليد
  Menoufiya Medical Journal / / Vol. 25, No. 1 - Janury 2012
  تاريخ تقديم البحث 02/12/2013
  تاريخ قبول البحث 03/12/2013
  عدد صفحات البحث 18
  Shahinaz H. EL-Shourbagy
  Sonographic parameters, AD-BPD difference, chest- BPD,
Humerospinous distance
  Background: Shoulder dystocia followed by permanent brachial
plexus injury or mental impairment is one of the leading causes of
malpractice allegations. Prompt assessment and management of
shoulder dystocia and preparation to maximize the efficiency of
shoulder dystocia maneuvers are critical. Study design:
Prospective cross sectional study of a reference group of healthy
pregnant women and a test group of women with risk factors for
shoulder dystocia. Outcome measures were difficulties with delivery
of shoulders and correlation with maternal body weight and birth
weight. Objectives: To determine the best Sonographic parameters
in prediction of shoulder dystocia in delivery at term. Patients and
Methods: The study included 60 selected pregnant women within
two weeks of delivery at Tanta University hospital. The chosen cases
were divided into two groups. The first ”reference” group (GI)
composed of 20 women with singleton normal pregnancy at 38-42
weeks. The second test group (GII) composed of 40 women at risk.
Risk factors include maternal obesity (Body mass index ’BMI’ > 30),
excessive prenatal weight gain (weight gain > 20 kg), previous
macrocosmic baby, history of difficult delivery, clinical suspicion of
large baby and diabetic women. Three ultrasonic parameters were
used for comparison between the two groups.
1. Difference between the abdominal diameter and biparietal
diameter (AD-BPD difference).
2. Difference between chest diameter - biparietal diameter (chest-
BPD difference).
3. Humerospinous distance measurement.
Results: During the study period, 45 women were admitted to
spontaneous labor, 10 underwent an induction of labor, and 5 had an
elective cesarean section. All cases of shoulder dystocia (n=10)
occurred among women who delivered vaginally with significant ADBPD
difference (P>0.05). Comparing the groups with and without
shoulder dystocia, significant differences were found in maternal
weight, weight gain, birth weight and AD-BPD difference, while in
other sonographic parameters measured (chest- BPD,
Humerospinous distance) the significant difference was only
detected at a cutoff value 2.6cm for AD-BPD difference (AD-BPD
difference> 2.6). Conclusion: Since some of these risk factors are
known prior to delivery, each woman especially those at high risk,
with significant AD-BPD difference should be counseled on her
individual risk of severe perinatal morbidity before a decision on the
mode of delivery is taken.
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[9000436.] رقم البحث : 9000436 -
EFFECT OF L-CARNITINE ON PILOCARPINEINDUCED /
  قطاع الدراسات الطبية / الصيدليه السريريه
تخصص البحث : الصيدليه السريريه
  Menoufiya Medical Journal / / Vol. 25, No. 1 - Janury 2012
  تاريخ تقديم البحث 02/12/2013
  تاريخ قبول البحث 03/12/2013
  عدد صفحات البحث 14
  ط/ محمد فاروق احمد سيد احمد
  hippocampus - l-carnitine - oxidative stress - pilocarpine - epilepsy
  Reactive oxygen species have been implicated in seizure-induced
neurodegeneration and there is a correlation between free radical level
and scavenger enzymatic activity in epilepsy. It has been suggested that
pilocarpine-induced seizures is mediated by an increase in oxidative
stress. Current research has found that antioxidant may provide, in a
certain degree, neuroprotection against the neurotoxicity of seizures at
the cellular level. L-Carnitine has a powerful antioxidant action. The
objective of the present study was to evaluate the neuroprotective effects
of L-Carnitine (L-CAR) in rats, against oxidative stress caused by
pilocarpine-induced seizures. 30 min prior to behavioral observation, rats
were treated with (0.9% saline i.p., control group), L-CAR 300 mg/k
alone (L-CAR 300 mg/kg i.p., L-CAR group), pilocarpine (400 mg/kg, i.p.,
P400 group) and the combination of L-CAR (300 mg/kg, i.p.) and
pilocarpine (400 mg/kg, i.p.). After the treatments all groups were
observed for 6 hr. The enzymatic activities, lipid peroxidation and nitrite
concentrations were measured using speccitrophotometric methods and
these data were assayed. In P400 group rat there was a significant
increase in lipid peroxidation and nitrite levels. However, no alteration
was observed in superoxide dismutase (SOD) and catalase activities. In
the L-CAR and pilocarpine co-administered rat, antioxidant treatment
significantly reduced the lipid peroxidation level and nitrite content, as
well as increased the SOD and catalase activities in rat hippocampus
after seizures. Our findings strongly support the hypothesis that oxidative
stress occurs in hippocampus during pilocarpine-induced seizures,
indicate that brain damage induced by the oxidative process plays a
crucial role in seizures pathogenic consequences, and imply that strong
protective effect could be achieved using l-carnitine. In conclusion: Lcarnitine
could enhance activities of SOD and reduce the MDA level and
could reduce seizure period, inhibit neuronal damage as free radical
scavenger.
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[9000437.] رقم البحث : 9000437 -
MOLECULAR DIAGNOSIS IN TYPE1 DI ABETES IN CHILDREN /
  قطاع الدراسات الطبية / الهندسه الوراثيه
تخصص البحث : الهندسه الوراثيه
  Menoufiya Medical Journal / / Vol. 25, No. 1 - Janury 2012
  تاريخ تقديم البحث 02/12/2013
  تاريخ قبول البحث 03/12/2013
  عدد صفحات البحث 10
  Khalil El-Halafawy
  T1D IDDM HLA DRB1 Genes SSP-PCR
  Background: In type1 diabetes (T1D) The most important genes are located
within the major histocompatibility complex(MHC) HLA class II region on
chromosome 6p21, a locus termed Insulin Dependent Diabetes Mellitus
(IDDM), which alone accounts for approximately 40-45% of the genetic
susceptibility to T1D. Association between autoimmune diseases and
alleles of genes in the MHC region is among the most consistent findings in
human genetics. Genes in the region are involved in the immune response
e.g. by presentation of antigenic peptides to T lymphocytes. But even though
the function of the proteins encoded by these genes is well known, their
specific contribution to the pathogenesis and the exact mechanisms by which
the locus confers susceptibility to immune- mediated destruction of the
pancreatic islets is still not clear.
AIMES: The aim of our study was to confirm the contribution of HLA-DDRB1
polymorphisms to T1D genetic susceptibility for the Egyptian children
population.
Patients and methods: Twenty IDDM children of 14 boys and 6 girls with
another twenty matched healthy subjects12 boys and 8 girls (as Control)
were studied. Using standard operating procedure (SOP) for peripheral –
blood-mononuclear cells (PBMC) (Isolation and cryopreservation, Protocol
used at KFSH&RC, Cross-Network Version 1:04 November2005) to
determine and comparing the frequency of HLA-DRB1*04
alleles(DRB1*0401,DRB1*0403 DRB1*0409 ,DRB1*0417, DRB1*0428
,DRB1*0436)(Table7) using Sequence Specific Primer-Polymerase Chain
Reaction (SSP-PCR).
Results: Three different significant alleles,DRB1*0401,OR: 7.364 , P=0.013
,DRB1*0403 ,OR:6.000,P=0.028 and DRB1*0428 , OR: 0.064, P=0.003.
DRB1*0409, DRB1*0417, DRB1*0401(Table7)
Conclusion: This study demonstrates that the susceptibility and protective
human lymphocyte antigen (HLA) alleles play an important role in T1DM in
the Egyptian children population.
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[9000438.] رقم البحث : 9000438 -
USE OF ULTRASOUND IN OSTEOMYELITIS DIAGNOSIS /
  قطاع الدراسات الطبية / جراحه العظام
تخصص البحث : جراحه العظام
  Menoufiya Medical Journal / / Vol. 25, No. 1 - Janury 2012
  تاريخ تقديم البحث 02/12/2013
  تاريخ قبول البحث 03/12/2013
  عدد صفحات البحث 10
  ط/ عمرو صابر السيد عمر ( 105461428 )
  osteomyelitis ; children ; ultrasound .
  Purpose: The purpose of this study was to determine the
diagnostic accuracy of ultrasonography for suspected
osteomyelitis. Patients and Methods: The use of ultrasound in
osteomyelitis has been studied in seventeen patients clinically
suspected of osteomyelitis. The patients were investigated
prospeclively with high - resolution ultrasonography for the
presence of subperiosteal fluid or cortical irregularity. A
sonographic diagnosis of osteomyelitis was made if fluid was
present in direct contact with the bone, without intervening soft
tissues. Results: Ultrasonographically 15 patients were found to
have osteomyelitis; diagnosis was established by surgery and
positive culture of the fluid found inta-operatively. Two patients
had soft tissue abscess. No cortical irregularity can be found.
Conclusion: Ultrascnographic results may help the diagnosis apart
from the importance of clinical judgment and results of other tests.
Two ultrasonograpbic studies were false - positive, and diagnostic
accuracy of ultrasound diagnostic procedure was 92%.
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