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SECI Oncology Journal /
بيانات الدورية
أعداد قيد الطبع
اعداد الدورية
  SECI Oncology Journal /
  
 

[9002155.] رقم البحث : 9002155 -
Adjuvant radiotherapy in breast cancer: A comparison of two accelerated hypofractionated protocols /
تخصص البحث : General
  SECI Oncology Journal / / vol.1 - 2013
  تاريخ تقديم البحث 28/10/2018
  تاريخ قبول البحث 28/10/2018
  عدد صفحات البحث 7
  شيماء السيد يوسف احمد - مؤلف رئيسي
  Adjuvant radiotherapy ,breast cancer
  Background: Accelerated hypofractionated approach is based on the radiobiologic model that a lower total dose delivered in fewer, larger fractions over a shorter period of time is at least as effective as the traditional longer schedule with increasing evidence of equivalent efficacy and toxicities from randomized trials comparing conventional radiotherapy schedules to different hypofractionated schedules. Patients and methods: 100 female patients having breast cancer after finishing their chemotherapy if indicated, randomized into two arms of accelerated hypofractionation; 39Gy/13 fractions (group A) and 42.4Gy/16 fractions (group B) both regimens given as 5 fractions per week. Results: The disease free survival was 93% and local recurrence was 1%. There were no statistically significant effects as regards recurrent rate in any studied factors. Radiation complications of patients, in terms of skin, subcutaneous, pulmonary, cardiac, ipsilateral arm lymphedema and brachial plexus toxicity, were assessed and graded in both group A and group B. There was significant increase of incidence of acute radiation dermatitis in patients receiving 39 Gy, as grade I and II reported in 82% and 46% for 39 Gy group and 42.4 Gy group respectively. In-addition, increased chronic subcutaneous fibrosis among patients with group A (28%) in comparison to group B (18%) that reach statistical significance. Type of surgery is the only factor that had significant effect on incidence of acute radiation dermatitis and chronic subcutaneous fibrosis. Conclusion: Our study concluded Equivalent efficacy of 39 Gy in 13 fractions and 42.4 in 16 fractions regarded local control and survival. 39 Gy in 13 fractions is not recommended for patients underwent BCS.
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[9002156.] رقم البحث : 9002156 -
P-Stat3Tyr705 expression in different cell population in chronic myeloid leukemia by flowcytometry /
تخصص البحث : General
  SECI Oncology Journal / / vol.1 - 2013
  تاريخ تقديم البحث 28/10/2018
  تاريخ قبول البحث 28/10/2018
  عدد صفحات البحث 8
  نهى جابر سيد احمد - مؤلف رئيسي
  chronic myeloid leukemia ,flowcytometry
  Background: chronic Myeloid Leukaemia (CML). It is a type of myeloproliferative disease associated with a characteristic chromosomal translocation t (9;22)(q34;q11). P-Stat3Tyr705 is activated in a bcr-abl independent manner by the cytokine milieu. Experimental evidence indicates that Stat3 plays a very crucial role in hematopoiesis. Additional research, however, suggested a more complex role for Stat3 in neutrophil regulation. Attractive to speculate that inhibition of p-Stat3Tyr705 activity would lead to drug sensitization and cell death in CML cells. Taken together, this study aims to assess the level of p-Stat3Tyr705 expression cell populations in CML patients and in normal controls involving each of myeloid and lymphoid cell populations. Methods: The study included 50 CML patients and 20 normal healthy controls. P-Stat3Tyr705 expression was assessed in each of myeloid and lymphoid cells as indicated by plotting analysis of the samples by flowcytometric analysis and gating these cell populations on the forward and side scatter. Results: This work revealed increase in the level of expression of p-Stat3Tyr705 in CML patients than in normal healthy controls regarding myeloid cells with no difference found regarding lymphoid cell population. Also it was encountered that the expression of p-Stat3Tyr705 is higher on myeloid cells than in lymphoid cells in CML patients. A difference which is not found in healthy controls. No correlation between p-Stat3Tyr705 and bcr-abl quantitation was detected. Conclusion: The increase in the p-Stat3Tyr705 expression over the myeloid cells is a part of the pathological events of the disease process and not found in the normal physiological conditions. The myeloid cells can be considered the pathologic target of p-Stat3Tyr705 over expression in the disease process.
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[9002157.] رقم البحث : 9002157 -
Daily repetitive high frequency transcranial magnetic stimulation of primary motor cortex for malignant neuropathic pain /
تخصص البحث : General
  SECI Oncology Journal / / vol.1 - 2013
  تاريخ تقديم البحث 28/10/2018
  تاريخ قبول البحث 28/10/2018
  عدد صفحات البحث 9
  شيرين ممدوح محمد كمال محمود - مؤلف رئيسي
  Motor cortex, rTMs, neuropathic pain, analgesia.
  Background: Background: Neuropathic pain in cancer patients can arise as a consequence of cancer- directed therapy, such as surgery, radiotherapy and chemotherapy. Significant analgesic effects of repetitive transcranial magnetic stimulation (rTMS) have been found in several studies of patients with chronic pain of various origins. Objectives: to assess the efficacy of daily 10 sessions of rTMS on primary motor cortex in patients suffering from malignant neuropathic pain. Material and methods: Thirty four patients were included in the study. They are divided randomly into 2 groups (17 patients for each) using closed envelop as real rTMS group and sham group. Real rTMS over the hand area of motor cortex (20 Hz, 10 trains with inter train interval 30 second with total pulses 2000, intensity 80% of motor threshold) every day for ten consecutive days (5 days/week) and the coil elevated and angled away from the head as sham stimulation. Patients were evaluated by verbal descriptor scale (VDS), visual analog scale (VAS), Leeds assessment of neuropathic symptoms and signs (LANSS) and Hamilton rating scale for depression (HAM-D) at the baseline, after 1st, 5th, 10th session, 15 day and 1 month after end of sessions. Results: There was no significant difference between true and sham groups in the duration of illness, VDS, VAS, LANSS scores at the base line. VAS, VDS and LANSS scores of the patients who received real rTMS decreased more over the course of the treatment through the different points of follow-up than those who received sham stimulation but not after one month follow up. Conclusion: The results confirmed that 10 sessions rTMS over the motor area can induce pain relief in malignant neuropathic pain for at least 15 days but the effect cannot be maintained after one month.
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