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تم العثور علي : 25
 تم العثور علي : 25
  
 
إعادة البحث

Periodical 1997
ISSN: 1097-1076
L التعليم   L تعليم ( عام )  
378 التعليم العالي  
Universities and colleges - Universities and colleges - Humanities - Humanities - Arts - Arts - Social sciences - Social sciences - Education - Graduate - Education - Graduate - Humanities - Humanities - Social Sciences - Social Sciences - Universities - Universities - Universitâes - Universitâes - Sciences humaines
Peterson’s,

Periodical 1997
ISSN: 1088-9442
L التعليم   L تعليم ( عام )  
378 التعليم العالي  
Universities and colleges - Universities and colleges - Business education - Education - Health occupations schools - Information science - Law - Social work education - Commerce - Education - Graduate - Information Science - Schools - Health Occupations - Social Work - Universities
Peterson’s,

Thesis 2021.
هناء محمد سيد،
610 الطب والعلوم الطبية   610 الطب والعلوم الطبية  
التمريض
تصفح الوعاء  

Thesis 2019
Tabash، Mohammed Suleiman Salem.
004 معالجة البيانات- الحاسب الآلي  
Intrusion Detection Systems (IDSs) - are the most
appropriate methods to prevent and detect the attacks of
networks and computer systems. The security system
development - in the computing world - still requires
accurate work. Artificial intelligence technique can make
IDSs easier than before. As always - the most important
thing is to know more about smart systems through training
to acquire the truth things. This thesis focuses on creating
an environment for IDSs to teach them to practice the work
such as a security officer. The study presents several ways
to discover network anomalies using data mining tasks -
deep learning technology. In this thesis - two smart hybrid
systems were developed to explore any penetrations inside
the network. The first model divides into two basic stages.
The first stage includes the Genetic Algorithm (GA) in
selecting the characteristics with depends on a process of
extracting - Discretize And dimensionality reduction
through Proportional k-Interval Discretization (PKID) and
Fisher Linear Discriminant Analysis (FLDA) respectively.
At the end of the first stage combining classifier Naïve
Bayes and Decision Table classifier using NSL-KDD data
divided into two separate groups for training and testing.
The second stage completely depends on the first stage
outputs in order to improve the performance in terms of the
maximum accuracy in classification of penetrations - raising
the average of discovering and reducing of the average of
false alarms through participation with the Deep Learning
(DL) technology and collaboration with an algorithm
(SGD). The second hybrid model relies upon Particle
تصفح الوعاء  

Book [2019] ,© 2019 by McGaw-Hill Education.
Geula, Erfun,
ISBN: 9781260453904 ,9781260453911 ,9781260453898
428 الاستخدام اللغوي المعياري  
Graduate Record Examination - Universities and colleges

Book 2011.
ISBN: 9781438070780 ,9780764146169
378 التعليم العالي   378.16 تقييم الطالب الجامعي  
Universities and colleges - Graduate Record Examination
Barron’s Educational Series, Inc.

Book 2015
ISBN: 9781137402134
L التعليم   L تعليم ( عام )   LB نظرية وممارسة التعليم، والتدريس  
370 التعليم   370 التعليم   370.1 الفلسفة و النظريات   370.15 علم النفس التربوي  
Creative thinking - Creative teaching - Creative activities and seat work - EDUCATION / Educational Psychology - EDUCATION / Experimental Methods - EDUCATION / Non-Formal Education - EDUCATION / Teaching Methods & Materials / General

Thesis 2017.
Awad, Basma Mosilhy Kassem.
615 علم الصيدلة والعلاج  
pharmacy - Abstract:
Historically - plants have been used since ancient times and in folklore for the treatment of many diseases and illnesses including chronic diseases and cancer care. In recent years - plants have been getting more attention as drugs worldwide.
Achillea fragrantissima (Forssk.) Sch. Bip. is a desert plant which belongs to Asteraceae family and is known as Qaysūm in Arabic. We selected it as a member of family Asteraceae to be the plant under investigation. It grows in Sinai - Egypt and is used in folk medicine by Bedouins for treatment of many diseases. In addition it has been tested for its anticancer activity. The broad aim of this thesis was to conduct a phytochemical investigation and biological confirmation of the plant Achillea fragrantissima (Forssk.) Sch. Bip. and its constituents as an anticancer agents illustrating their mechanism of action.
The initial part of this work focused on large scale extraction of the plant with different solvents - bioactivity-guided fractionation led to the isolation of seven compounds followed by determination of the chemical nature of them. The isolated compounds are:
The known compounds Eupatilin 7- methyl ether (3) - chrysosplenol D (4) - Cirsiliol (5) - β-Sitosterol-3-O-β-D-glucoside (6) and Cirsimaritin (7) while Piceol (1) and Veratric acid (2) are reported here for the first time from Achillea fragrantissima (Forssk.) Sch. Bip.
The second part of this work focused on evaluation of the in-vitro cytotoxic activity of the methanolic extract of A. fragrantissima (Forssk.) Sch. Bip - its fractions and the isolated compounds 1 - 2 - 3 - 4 - 5 and 7 against different cell lines using the Sulpho-Rhodamine-B (SRB) assay. The extract - fractions (4 - 5) and the compounds 3 - 4 - 5 and 7 showed high cytotoxic activities when compared to appropriate reference drug (doxorubicin) and IC50 values (the concentrations of drug required to produce 50% inhibition of cell growth) were calculated for the isolated compounds.
The third part of this work focused on evaluation of the in-vivo antitumor activity of the methanolic extract of A. fragrantissima (Forssk.) Sch. Bip. and its isolated compounds 3 - 4 - 5 and 7 using Ehrlich’s Ascites Carcinoma (EAC) model in mice. A. fragrantissima (Forssk.) Sch. Bip. extract and its isolated compounds reduced the tumor weight compared to EAC-Control group. In addition - the compounds 3 - 7 treatments produced a dose dependent reduction in tumor weight. Determination of serum tumor necrosis factor – alpha (TNF-α) level highlighted that A. fragrantissima (Forssk.) Sch. Bip. extract and its isolated compounds significantly reduced its serum level compared to the EAC-Control group - where 3 - 5 - 7 groups produced a significant reduction in serum level of TNF-α compared to all other groups. Furthermore - A. fragrantissima (Forssk.) Sch. Bip. extract and the isolated compounds significantly increased the total antioxidant capacity (TAC) compared to EAC-Control especially compound 7. The histopathological examination revealed that A. fragrantissima (Forssk.) Sch. Bip. extract and its isolated compounds produced a better differentiation of tumor cells - with reduced nuclear pleomorphism and better formed tubular structures especially with high dose indicating the induction of apoptotic mechanism.
Finally - an in silico study was performed as a step to elucidate the mechanism of the cytotoxic effect of the compounds isolated from A. fragrantissima (Forssk.) Sch. Bip - where the structure of cirsiliol (5) was docked into the active sites of the crystal structures of PI3K and Akt - two protein kinases that are significantly involved in prostate and breast cancer processes.
Key Words: Achillea fragrantissima (Forssk.) Sch. Bip - anticancer - Ehrlich’s Ascites Carcinoma - Docking.
Aim of work:
Flora of Egypt especially in Sinai Peninsula is rich and diverse with medicinal and aromatic plants as well as herbs and spices. These plants have been used by local people in folk medicine for curing human and animal illnesses. The plants of genus Achillea as a part of Sinai Peninsula flora were and still a rich source of valuable natural products for treatment of many diseases; therefore - this study was designed to fulfill:
1. Collection of the plant material from Sinai Peninsula in Egypt.
2. Bioactivity-guided fractionation to isolate active compounds using different chromatographic techniques.
3. Identification and structure elucidation of the isolated compounds - using 1D NMR - 2D NMR and DEPT measurements.
4. In vitro cytotoxic and in vivo antitumor evaluations of the methanolic extract of Achillea fragrantissima (Forssk.) Sch. Bip. and its isolated compounds.
pharmacognosy
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Book [2016] ,©2016
ISBN: 1506203213 ,9781506203218
H العلوم الأجتماعية   HF التجارة ( بصورة عامة )   HF 1 التجارة  
650 إدارة الأعمال   650 إدارة الأعمال  
Graduate Management Admission Test - Management - Business schools - Universities and colleges - Graduate management admission test - Management

Book [2016] ,آ©2016.
ISBN: 1506203213 ,9781506203218
H العلوم الأجتماعية   HF التجارة ( بصورة عامة )   HF 1 التجارة  
Graduate Management Admission Test - Management - Business schools - Universities and colleges


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