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العنوان
Role of Pro-Inflammatory Cytokines Interleukin-1
and Interleukin-6 as Systemic Regulators of
Overweight and Obesity in Children /
المؤلف
Aly, Ahmed Gamal Samy.
هيئة الاعداد
باحث / أحمــد جمــال سامــى علــى
مشرف / هويدا حسنى الجبالى
مناقش / حامد أحمد الخياط
مناقش / محمد خليل محمد عبدالخالق
تاريخ النشر
2022.
عدد الصفحات
171 P. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
طب الأطفال ، الفترة المحيطة بالولادة وصحة الطفل
تاريخ الإجازة
1/1/2022
مكان الإجازة
جامعة عين شمس - معهد الطفولة - قسم الدرسات الطبية للأطفال
الفهرس
Only 14 pages are availabe for public view

from 171

from 171

Abstract

Cases of childhood obesity are on the rise these days and there are enough reasons which contribute to the growing numbers. The major contributors to this rise is sedentary lifestyles and bad eating habits. There aren’t many facilities for playing games like football, basketball or even running. Moreover, they have options aplenty at home like watching TV, playing video games, mobile and computer games. This reduces their physical activity to a large extent.
Moreover, the easy availability of junk foods like pizzas, fries, burgers which are high in unsaturated fats and are difficult to digest also add to the problem. ’These days, both parents are working in most families and kids are at the mercy of maids who don’t necessarily take care of their diet. Even in joint families, grandparents over pamper kids by offering sweets and chocolates which attributes to weight gain.
The magnitude of the problem urges to have a reliable predictor for childhood obesity and overweight. Human IL-6 is regarded as the major inflammatory mediator having both pro- and anti-inflammatory effects. Furthermore, IL-1 is a pro-inflammatory cytokine chronically elevated in the presence of obesity. And since obesity is a chronic inflammatory state, indicated by the increased expression, production, and release of a number of inflammation-related adipokines, thus comparing both of these groups (Obese and Overweight) as regards interlukin-1 and interlukin-6 (pg/ml) levels showed highly significant higher interlukin1 (pg/ml) and interlukin 6 levels in obese and overweight groups compared to control group. They were highest in the obese group followed by overweight group and was lowest in the control group.
Conclusion
Obese and overweight children have high levels of Interleukin-1 and Interleukin-6. These are closely related and significant with mean blood pressure, blood sugar and lipid profile of those children.
Traditional methods of weight management, such as strict diets, don’t always work and can sometimes be unhealthy. Teaching healthy habits – including physical activity, nutrition, good sleep and reducing stress – is another way parents and caregivers can work toward decreasing childhood obesity.
Studies are showing is that the most effective treatment involves early detection and early intervention through family based behavioral treatments, where families are taught about behavioral strategies to help change the home environment.
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Recommendations
• Further studies on larger scales including larger number of children from all over Egypt (urban and rural areas) to estimate the correlation between Interleukin-1 and Interleukin-6 with the actual prevalence of obesity and overweight among primary school children of different social classes with age ranging 6 -12 years.
• Regular follow up of obese and overweight children by measuring their blood pressure, serum glucose, glycosylated hemoglobin, lipid profile to offer early intervention and proper treatment when needed.