الفهرس 
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Abstract
Sepsis is considered one of a life-threatening condition among intensive care unit (ICU) patients. Although, there are evidence-based management guidelines, sepsis still remains a leading cause of death with in-hospital mortality ranging from 22.8% to 48.7% (Seymour et al., 2017).
Previously sepsis was defined as systemic inflammatory response to infection, which could be diagnosed by meeting two or more Systemic Inflammatory Response Syndrome (SIRS) criteria, along with a known or suspected infection (Abe et al., 2020). Even though the SIRS criteria were sensitive, but they were not specific enough to differentiate between sepsis and other inflammatory conditions.
(SOFA score), sepsis-related organ failure assessment score, also known as sequential organ failure assessment score,is used to track a person’s status during the stay in an intensive care unit (ICU) to determine the extent of a person’s organ function or rate of failure. The score is based on six different scores, one each for the respiratory, cardiovascular, hepatic, coagulation, renal and neurological systems (Vincent et al., 1996).
The Quick SOFA Score was introduced by the Sepsis-3 group in February 2016 as a simplified version of the SOFA Score as an initial way to identify patients at high risk for poor outcome with an infection. The score ranges from 0 to 3 points. The presence of 2 or more qSOFA points near the onset of infection was associated with a greater risk of death or prolonged intensive care unit stay (Angus et al., 2016).
We aimed in this study to compare between the ability of SOFA score, the quick SOFA (qSOFA) and Systemic Inflammatory Response Syndrome (SIRS) to predict ICU mortality.
Patients and methods
A Randomized prospective comparative study conducted in EL Haram Specialized Hospital and included 75 patients who were admitted to ICU and had met 2 or more criteria of sepsis according to SIRS score:
Body temperature above 38 °C or below 36 °C,
Heart rate more than 90 beat/min,
Respiratory rate more than 20 breath/min
White blood cell count ≥ 12,000/mm3 or ≤ 4000/mm3. (Raith et al., 2017)
We calculated SOFA, SIRS, and qSOFA scores based on physiological and laboratory data that were collected upon admission to the ICU. Standard criteria were applied with a threshold of 2 or more points for each scoring system. The baseline SOFA score was assumed to be zero for patients without a known preexisting organ dysfunction. The baseline total SOFA score was considered to be 4 for patients undergoing chronic dialysis, and 2 or 3 for cirrhotic patients, depending on baseline bilirubin levels.
Results
ROC curve analysis between survival and each of SIRS, qSOFA and SOFA, it shows that SOFA score presented the best discrimination with an AUC of 0.993 (95% CI 0.981–100).
Conclusion
Increase in SOFA score had greater prognostic accuracy for in-hospital mortality.