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العنوان
Comparative study of some regimes efficiency and
their effects on both of obese and diabetic
experimental rats /
المؤلف
Ibrahim, Rabab Mohamed Aboelsoud.
هيئة الاعداد
باحث / رباب محمد أبوالسعود إبراهيم عامر
مشرف / أسامة السيد مصطفي
مشرف / محمد عبد المنعم محمد
مشرف / ولاء إبراهيم محمد أنيس
تاريخ النشر
2020.
عدد الصفحات
109 P. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
اقتصاد منزلي
تاريخ الإجازة
1/1/2020
مكان الإجازة
جامعة عين شمس - كلية التربية النوعية - قسم الاقتصاد المنزلى
الفهرس
Only 14 pages are availabe for public view

from 109

from 109

Abstract

Obesity is a well-recognized risk factor for the development of glucose intolerance, diabetes type II, and metabolic syndrome; it has been correlated with prostate, colorectal, breast, and ovarian cancer; and, in addition, it increases the risk of thrombosis, rheumatic degenerative disorders, gallbladder stones, hepatopathies, and respiratory diseases. But the strictest correlation has been found between overweight and cardiovascular diseases: Obesity increased the risk of heart failure both in women and in men.
Diabetes is on the rise. Globally, an estimated 422 million adults were living with diabetes in 2014, compared to 108 million in 1980, in 2012 alone diabetes caused 1.5 million deaths. Its complications can lead to heart attack, stroke, blindness, kidney failure and lower limb amputation.
The present study aimed to investigate the effect of some popular diet, as ”Atkins” diet, Zone , MD, and Zero carbohydrate diet on reduction, weight, blood sugar, and their effects on lipid profile, leptin and adiponectin, liver functions, renal functions and Histopathological characteristics of some organs in the experimental rats.
The study was conducted on 88 rats from male albino rats (Sprague Dawley strain), with average weight of about 150 ± 2g. The rats were divided into three main groups.
- First main Group: negative control group (1) fed on standard diet.
- Second main Group: experimental group, with induced obese, which were divided into 5 sub-groups;
Subgroup: positive obese control group (2) fed on high fat/ high protein diet.
Sub-group (3) fed on Zero diet.
Sub-group (4) fed on Zone diet.
Sub-group (5) fed on Atkins diet.
Sub-group (6) fed on Mediterranean diet.
- Third Group: induced experimental group with diabetes were divided into 5 sub-group.;
Sub-group (7) positive diabetes control fed on standard diet.
Sub-group (8) fed on Zero diet.
Sub-group (9) fed on Zone diet.
Sub-group (10) fed on Atkins diet.
Sub-group (11) fed on Mediterranean diet.
At the end of experimental period, rats were fasted overnight and anesthetized. Blood samples were collected from the hepatic portal vein into clean, dry centrifugation tube, and serum was separated by centrifugation, 15 minutes at 3000 rpm, at room temperature and kept frozen at -20o C until analysis.
Results could be summarized as follows:
First part (obesity rats):
1- There were significant differences (p≤0.05) among all studied groups of experimental rats in body weight-loss, the results revealed Zero diet (24.7%) was the lowest then MD diet (22%).
2- There were decreased significantly (p≤0.05) among all studied groups of experimental rats in triglycerides compared control positive group, Zone diet was the lowest then MD diet.
Likewise, total cholesterol decreased significantly (p≤0.05) in MD diet then Zone diet, as for HDL-c was increased significantly (p≤0.05) in all treated groups in particular MD diet
- For LDL-c decreased significantly in all treated groups, MD diet was the best then Zone diet.
3- There were decreased significantly (p≤0.05) among all studied groups of experimental rats in AST enzyme, Atkins was the lowest then Zone diet, for ALT enzyme was decreased in all treated groups (MD diet was the lowest, but Zero diet was higher than positive control group.
- Finally, ALP enzyme was increased significantly (p≤0.05) in all treated groups compared to positive control group except MD diet.
4- There were decreased significantly (p≤0.05) among all studied groups of experimental rats in urea nitrogen except Zero diet and MD diet was the lowest compared to positive control group.
- Meanwhile, the serum uric acid decreased significantly (p≤0.05) among all treated groups. The lowest results were Zone diet then MD diet respectively.
- As for creatinine serum observed decreased significantly (p≤0.05) among all treated groups, the lowest was Zone diet.
5- There were decreased in blood sugar but non-significant in all treated groups compared to positive control groups.
6- Leptin hormone of all treated groups recorded significant decreased at (p≤0.05) as compared to positive control groups while, adiponectin increased significantly (p≤0.05) for all studied groups.
7- The present investigation revealed that undesirable change in all treated groups, but it was slight change in MD diet.
Results could be summarized as follows:
Second part (diabetes rats):
1- There were significant differences (p≤0.05) among all studied groups of experimental rats in body weight-loss, the lowest was MD diet, and then Zero and Atkins diet.
2- There were increased significantly (p≤0.05) among all studied groups of experimental rats in triglycerides (except MD diet) compared control positive group.
- For total cholesterol of all treated groups increased no significantly (p≤0.05) compared to positive control group except MD group. Also, HDL-c increased no significantly in all treated group.
- There were increased significantly (p≤0.05) among all studied groups of experimental rats in LDL-c (except MD diet) compared to positive control group and the same for v-LDL-c.
3- There are increased significantly (p≤0.05) in AST enzyme among all treated groups, MD was the lowest compared to positive control group, while ALT enzyme decreased significantly (p≤0.05) in all treated groups (except Zero diet) compared to positive control group.
- Finally, ALP enzyme was increased significantly (p≤0.05) in all treated groups compared to positive control group except Atkins diet.
4- There were decreased in urea nitrogen in groups treated with Atkins and MD diet but not significant, while groups treated with Zero and Zone diet were increased significantly (p≤0.05) compared to positive control group.
- As for uric acid observed decreased significantly (p≤0.05) in all treated groups except Zone diet and creatinine was decreased significantly in all treated groups, with acceptance MD diet then Atkins diet compared to positive control group.
5- Blood sugar decreased significantly (p≤0.05) in all treated groups, the lowest was Atkins then MD diet compared to positive control group.
6- There were decreased significantly (p≤0.05) in all treated groups in leptin hormone, while it was increased significant in adiponectin hormone in all treated group except Atkins diet.
7- The present study observed undesirable change in all treated groups, but it was slight change in MD and Zone diet.