الفهرس 
DIABETES MELLITUS
Pathophysiology of Diabetic DyslipedemiaOnly 14 pages are availabe for public view
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Abstract
Diabetes mellitus is a worldwide major health problem with
approximately 5% of the world’s population suffering from the
disease. It is a disease caused by reduced insulin production or impaired
insulin response in target organs. It is characterized by high blood glucose
levels, abnormal metabolism of carbohydrates, proteins and fat. Such
alterations causes long-term complications in many organs. The effective
control of blood glucose is the key in preventing or reversing diabetic
complications and improving the quality of life for both type I and type II
diabetic patients. Although different types of oral hypoglycemic agents
are available along with insulin for the treatment of DM none offers
complete glycemic control.
Traditional plant medicines are used throughout the world for a
range of diabetic presentations. Therefore, an investigation of such agents
from traditional medicinal plants has become particularly important. One
of the known traditional medicinal plants is mulberry. Mulberry is a tree
belonging to the genus Morus of the family Moraceae. MBL are a known
traditional medicine for preventing DM, its anti-diabetic effect was
contributed to α-glucosidase inhibitory activity thus acting as a preventive
and therapeutic agent for type 2 DM and its complication. The present
study aimed to study and evaluate the therapeutic efficacy of MBL in
diabetic animal model.The results have shown that:
1) Mulberry leaves including both FMBL and DMBL have successfully
reduced blood glucose level in STZ injected rats
2) Mulberry leaves including both FMBL and DMBL have shown a
positive effect on diabetic dyslipedemia by decreasing the increased
level of LDL, TAG, TC and increasing the decreased level of HDL in
STZ injected rats.
3) Mulberry leaves including both FMBL and DMBL have affected the
oxidative stress resulted from diabetic complication by decreasing the
increased level of GSH-Px, SOD antioxidants and also decreasing the
increased level of lipid peroxidation product (MDA).