الفهرس 
Hepatic EncephalopathyOnly 14 pages are availabe for public view
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Abstract
Calprotectin is a calcium and zinc-binding protein, representing
more than 60% of the cytosolic proteins in neutrophils. The presence of
calprotectin in feces quantitatively relates to neutrophil migration into the
gastrointestinal (GI) tract. Therefore, it is considered as a valid marker of
intestinal inflammation because it is released during cell activation and
death.
To assess the value of fecal calprotectin as a screening test for
diagnosis of certain complication of cirrhosis as hepatic encephalopathy,
spontaneous bacterial peritonitis and hepatorenal syndrome in Egyptian
cirrhotic patients.
This study was conducted at the faculty of medicine, Ain Shams
university hospitals from March 2013 up to October 2014 included 80
patients, 20 control and they were divided into five groups:
1. 20 healthy non cirrhotic subjects as a control
2. 20 patients with liver cirrhosis without complications
3. 20 patients with liver cirrhosis complicated by SBP
4. 20 patients with liver cirrhosis complicated by HE
5. 20 patients with liver cirrhosis complicated by HRS
We found that
There’s statistically highly significant difference between the
studied groups(Control, Cirrhosis, SBP, HE and HRS) as regard
various laboratory data by using one way ANOVA test There’s statistically highly significant difference between studied
groups(Control, Cirrhosis, SBP, HE and HRS) as regard fecal
calprotectin by using one way ANOVA test
There’s statistically significant inverse correlation between fecal
calprotectin versus albumin among cirrhotic group by using
correlation coefficient test.
There’s statistically significant inverse correlation between fecal
calprotectin versus Na among hepatic encephalopathy group by
using correlation coefficient test.
There’s statistically significant inverse correlation between fecal
calprotectin versus RBS among SBP group by using correlation
coefficient test.
Fecal calprotectin has sensitivity of 90% and specificity of 60% in
prediction of HE with PPV and NPV of 67% and 94% respectively
at cut of value of 280mg/kg with AUC of 0.72.
Fecal calprotectin in SBP has sensitivity of 95% and specifity of
43% with PPV and NPV of 50% and 96% respectively at cut of
value 190mg/kg with AUC of 0.47.
Fecal calprotectin in HRS has sensitivity of 90% and specificity of
88% with PPV and NPV of 90% and 97% respectively at cut of
value of 340mg/kg with AUC of 0.94