الفهرس 
AcknowledgementOnly 14 pages are availabe for public view
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Abstract
The respiratory tract has become an increasingly attractive route of application for a wide spectrum of drug substances. Administration of drugs via the lung is convenient and enables patients to avoid the need for painful injections. While many of these substances have long been valued for their local effectiveness in the treatment of several pulmonary diseases, the ten towards a systemic application of drug products via the lung is rapidly gaining momentum.
Aerosols are and effective method to deliver therapeutic substances to the respiratory tract. Among aerosol generation systems, dry powder inhalers present several advantages. They are propellant-free, easily coordinated with the respiratory cycle and cause a relatively small drug entrapment in the oropharynx. In addition, they improve the stability of the formulation as a result of the dry state and require only portable and low cost devices. The challenge of any inhalation delivery system is to generate particles with an adequate range of particle sizes. To advance powder aerosol technologies, searchers have recognized the importance of investigating the determinants affecting powder dispersion. The effect of particle surface characteristics, environmental conditions, air flow rate, and excipients, on aerosol generation are some of the fundamental areas that have been under investigation