الفهرس 
Review of literatureOnly 14 pages are availabe for public view
 |  | from | 202 |  |  |
| | | from | 202 | | |
Abstract
Severe birth asphyxia with development of hypoxic ischemic brain " ~ "amage in newborn is one of the most common causes of neurological ,disability in children. Perinatal asphyxia occurs in both preterm and fullterm infants especially those with breech delivery and intrauterine Asphyxia is strictly defined as the combination of acidosis, and impaired organ function. Target organs lof perinatal asphyxia include the brain, kidney, heart, lung, bow" ~ "l and bone marrow. Hypoxic ischemic encephalopathy (HIE) is the effect of perinatal asphyxia on the brain. Endothelin 1 (ET 1) IS a potent endothelium-derived ; vasoconstrictor peptide , formed of 21 amino acids. Its effect on blood vessels is initial vasodilatation followed by sustained vasoconstriction. It is released from vascular endothelial cells, kidney, spleen, skeletal muscles and lung cells under the effect of hypoxia. Plasma ET 1 level is increased in many pathological conditions associated with tissue hypoxia such as acute renal failure, surgical stress, acute myocardial infarction and intracranial hemorrhage. The present study was intended to assess plasma ET 1 level in newborn with HIE in the first and fifth day of life to detect any disturbances in plasma ET 1 level in those patients and to uncover any role ofET 1 in the organs injury occurring during perinatal asphyxia. For this purpose, we had chosen 30 newborns with HIE admitted to the Neonatal Care Unit (NCU) of Mansoura University Hospital