الفهرس 
Introduction
Difference between the active sites of cyclooxygenaseOnly 14 pages are availabe for public view
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Abstract
The thesis comprises three main chapters : The first chapter is concerned with an introduction which deals with literature survey for the pathophysiology, etiology and current lines of treatment for rheumatoid arthritis. This survey includes the chemistry of prostaglandin hydrogen synthase (PGHS), The second chapter is related to the experimental part which describes the preparation of oxicam nucleus, piroxicam, copper piroxicam complex, zinc piroxicam complex and EX14u. Pharmacological techniques which have been used to study the biological activity of the studied compounds . The third chapter is concerned with the results and discussion. It is divided into two parts: Part one Comparison between market and the synthesized piroxicam by both Chemical characterization and Pharmacological tools. The two piroxicams are similar. Chemical characterization and Pharmacological evaluation were used for the synthesized piroxicam copper(II) and zinc(II) complexes . Part two This part is divided into three sections : Section 1 It is concerned with quantitative structure activity relationship (QSAR) to predicate a more selective compound against COX2 from different proposed compounds. Among them is EX14u Second section It is concerned with : a) Chemical Characterization of EX14u. b) Chemical Characterization of EX14uCopper(II) complex. The pharmacological COX2 selectivity of EX14u is in accordance with the estimated chemical COX2 selectivity obtained from QSAR.