الفهرس 
introduction and aim of the workOnly 14 pages are availabe for public view
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Abstract
Phenylketonuria (PKU) is an inherited metabolic disease, carried through a ?recessive? gene involved in the absence or partial inhibition of the enzyme phenylalanine hydroxylase, and consequently interrupt the conversion of amino acid phenylalanine to another amino acid, tyrosine resulting in mental retardation and other neurological problems. In the present study, experimental induction of phenylketonuria was carried out in order to assess the anatomical and structural developmental effects of the disease during postnatal development of albino rats. The disease was induced in pregnant females at the 6th day of gestation by daily intragastrically administered 30 mg. DL alpha methylphenylalanine/100 g. body weight plus 60 mg/lOOg body weight L phenylalanine at 12 h intervals throughout pregnancy till parturition as well as throughout lactation period till 28 days postpartum . Fifty pregnant were arranged into two main groups; Control and experimental phenylketonuric groups. The postnatal youngs of each control and experimental group were separated at parturition as well as at 1 ,2,3 &4 weekage. The present results summarized as follows : PKU pregnants showed much more retardation of growth weight during pregnancy. In postnatal youngs of PKU mothers, there was a marked decrease of mean body weight during postnatal growth. The absolute brain weights reduced during postnatal growth of PKU mothers The absolute brain weights were markedly reduced during postnatal growth of PKU mothers at parturition as well as at 1, 2, 3 & 4 weeks postpartum.