الفهرس 
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Abstract
Twenty four adult male albino rats (Ratus ratus), with average body weight between 150-200gm were used in this study. They were divided into two groups. The first group (control) includes Intact control group: the left submaniblar
gland of the denervated rats (16 rats) and experimental control group (sham operated group) comprised of 8 rats. The second group (16 rats), experimental group, was subjected to unilateral parasympathetic denervation of the right
submandibular gland by cutting the chorda tympani nerve in the middle ear.
Both operated and sham animals were allowed to survive for 1,2,3 and 4 weeks,t the assigned time, four animals from the experimental group and two rats from the sham operated group were sacrificed. Submandibular gland of sham and experimental groups (operated side) were carefully dissected and excised.
and prepared as parrafin sections for haematoxylin and eosin and PAS stains. Cryostat sections were cut at a thickness of 8 and 15 um using freezing microtome for NADPH-diaphorase stain.
Trans-tympanic destruction of the chorda tympani resulted in atrophic progressively smaller in about 90% of the acini. The cells of the atrophic acini became progressively smaller in size with scanty cytoplasm. There was loss of cell boundaries.
Two weeks after chorda tympani neurectomy, the atrophic acini
less packed. Cytoplasmic vacuolations appeared in the cells of the atropic acini and striated ducts. The ductal lumen did not show any dilatation.
By NADPH-diaphorase histochemical technique the normal distribution of NADPH-diaphorase positive nerve fibers could be detected. Delicate NADPH-diaphorase positive nerve terminals have been detected around both serous and
mucous acini of the control glands