الفهرس 
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Abstract
Transient tachypnea of the newborn (TTN) is the most frequent cause of early respiratory distress because of delayed resorption of the fetal lung fluid, which fills the fetal airways. The inability of the fetal lung to switch from fluid secretion to fluid absorption and an immaturity in the expression of the ENaC may play an important role in the development of TTN.
The aim of the current study was to evaluate the efficacy of inhaled salbutamol for the treatment of TTN.
This study was conducted as a randomized, prospective clinical trial of inhaled salbutamol on 34 neonates who were admitted immediately or shortly after birth in the neonatal intensive care unit of pediatric department, Zagazig university Hospital.
The Study group was diagnosed clinically and radiologically. Patients with respiratory distress syndrome, sepsis, pneumonia, meconium aspiration, apparent congenital cardiac diseases, perinatal asphyxia, congenital malformations and non respiratory disorders (hypocalcemia, persistent hypoglycemia and polycythemia) were excluded.
Written Informed consents were obtained from parents or care givers then all the neonates included in the study were subjected to history taking, clinical examination and investigations.
Investigations included: capillary blood gases, Complete blood count, C–Reactive protein (CRP), Serum glucose and Chest X-ray.
The response to inhaled drug therapy was evaluated by determining clinical score of transient tachypnea of the newborn and the level of respiratory support before and after inhaled therapy.
The duration and level of total respiratory support will be assigned along with the duration of hospitalization.
Follow up of the neonates was done by Oxygen saturation assessment by pulse oximetry, Arterial blood gases (ABG) and Determination of the duration of oxygen support and hospital stay.
Data were statistically analyzed using SPSS 15.0 for windows (SPSS Inc., Chicago, IL, USA).
Comparing study groups after 4h of inhaled therapy, highly significant lower TTN score, respiratory support and duration of hospitalization were detected in group I (salbutamol) than in group II (saline).
Regarding ABG findings after inhaled therapy, PH and PaO2 were significantly higher in group I than group II, PaCO2 was significantly lower in group I than group II. No significant difference detected between 2 groups regarding Serum glucose and Hemoglobin.