الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
One of the leading causes of morbidity and mortality worldwide is liver cirrhosis which is caused by a wide range of chronic diseases that progress slowly over years or decades. Cirrhosis has a silent asymptomatic course (compensated phase) until it becomes symptomatic due to increased portal pressure and the deterioration of liver function (decompensated phase). The thyroid gland produces two-related hormones that play a critical role in cell differentiation and help in maintaining thermogenic and metabolic homeostasis in adults. The relation between liver and thyroid hormones is bidirectional as the liver plays a central role in thyroid hormones metabolism, transport, clearance, and the peripheral conversion of T4 to T3. While T4 and T3 regulate the basal metabolic rate of all cells, including hepatocytes, and thereby modulating hepatic function. SO, Thyroid dysfunction may perturb liver function, while liver disease can modulate thyroid hormone metabolism. Our study aimed to assess the effect of liver cirrhosis on thyroid functions and its relation to the severity of liver disease. This cross-sectional study was conducted in Tropical medicine and infectious diseases department, Tanta University in the period between July 2021 to July 2022 after gaining approval of Tanta university ethical committee. Informed written consent was obtained from each subject before participation in the study. 90 subjects who met our inclusion criteria were enrolled then they were divided into three groups; group I included 35 cirrhotic compensated patients, group II included 35 cirrhotic decompensated patients and group III included 20 apparently healthy age and sex matched individuals as a control group.