الفهرس 
KDIGO Classification of Grades of CKDOnly 14 pages are availabe for public view
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Abstract
chronic kidney disease (CKD) refers to a state of irreversible kidney damage and/or reduction of kidney function that is associated with progressive loss of function over time.
Kidney Disease: Improving Global Outcomes pediatric definition and diagnosis of pediatric CKD based on fulfilling one of the following clinical criteria:
• GFR of less than 60 mL/min per 1.73 m2 for greater than three months with implications for health regardless of whether other CKD markers are present.
• GFR greater than 60 mL/min per 1.73 m2 that is accompanied by evidence of structural damage or other markers of kidney function abnormalities including proteinuria, albuminuria, renal tubular disorders, or pathologic abnormalities detected by histology or inferred by imaging. This category also includes patients with functioning kidney transplants.
Mean platelet volume (MPV) is a machine-calculated measurement of the average size of platelets found in blood and is typically included in blood tests as part of the CBC. Since the average platelet size is larger when the body is producing increased numbers of platelets, the MPV test results can be used to make inferences about platelet production in bone marrow or platelet destruction problems.
Our study was done to determine the relationship between Mean Platelet Volume & estimated Glomerular Filtration Rate in children with chronic Kidney Disease.
This study was performed in the period from May 2018 to February 2019 and with screening of CKD Children patients who admitted to Nephrology Unit of Pediatric Department of Zagazig University Hospitals. Only Patients (male and female) aged from 1-14 years with chronic Kidney Disease lasting ≥ 3 months and who having frequent dialysis or conservative treatment and their Estimated GFR equal or less than 60 ml/min/1.73 m²are included in our study but Patients having history or receiving treatement affecting hemostasis or platelets as Malignancy,Haematologic disorders (as ITP) and chronic Liver disease have been excluded.
All subjects of this study were subjected to Clinical examination including detailed history taking with s special considerations for age, sex, Co-morbidities and medications.
Full physical examination was done. Laboratory investigations: They were done according to the methods applied in the Clinical Pathology and laboratories of Zagazig University Hospitals and included: complete blood picture, liver function tests, kidney function tests, were done to all patients.
Our results documented that:
There is a significant difference between the two studied groups as regard weight.
There is significant difference between the two groups regarding SBP and DBP.
There is high significance difference between the two groups regarding Hemoglobin, MPV There is a significant difference between the two groups regarding serum creatinine, urea and eGFR and RDW
There is a significant difference between the two groups regarding serum albumin.
There is a positive significant correlation between MPV with RDW and creatinine and a negative correlation between MPV and eGFR in CKD group.
Conclusion
• MPV showed a negative correlation with eGFR in Children patients with CKD. A higher MPV was noted in patients with progressive CKD than in those with early stage CKD.
• The useful estimation of MPV provides a promising Cheap Biomarker in the monitoring of the course of progression in chronic Kidney Diseased Children.