الفهرس 
TYPE 1 DIABETES MELLITUSOnly 14 pages are availabe for public view
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Abstract
ABSTRACT
Background: Type 1 diabetes mellitus (T1DM) has many related microvascular and macrovascular complications. Increased risk of bone impairment have already been reported in individuals with T1DM. The serum levels of the bones turnover markers (BTM), serum procollagen type 1 N-terminal propeptide (P1NP) and serum C-terminal telopeptide of type I collagen (CTX), can help identify increasing bones fragility in T1DM earlier on.
Aim: The aim of the study is to measure the levels of BTM in children with T1DM, specifically serum P1NP and serum CTX, and to look into the relationships between BTM and indicators of glycemic control.
Patients and Methods: A total of 40 pediatric and adolescent T1DM children were compared with a control group of healthy control, age- and sex-matched participants. HbA1c, fasting lipids profiles, microalbumin in urine, fasting serum P1NP, and serum CTX concentrations were measured in the laboratory.
Results: P1NP and CTX concentrations in the sick group were statistically significantly higher than those in the control group (p (p<0.001), according to the findings of our research. LDL-C and TDD of insulin, which rose in the uncontrolled sample, were determined to differ significantly between participants with HbA1c ≤7% and participants with HbA1c ≥7% (p Conclusion: In T1DM children, serum concentrations of P1NP and CTX can offer predictive information on bones health. To demonstrate that oxidative stress causes major changes in the activities of bone production and resorption, more research should be conducted.