الفهرس 
Aim of the work
3.3 Irisin and Adipose TissueOnly 14 pages are availabe for public view
 |  | from | 154 |  |  |
| | | from | 154 | | |
Abstract
SLE is a multisystem autoimmune disease that
commonly affects females in the childbearing period, lupus nephritis
is one of the most serious manifestations of SLE, most cases of lupus
nephritis develop within the first 5 years of diagnosis of SLE, the
clinical presentation of LN ranges from asymptomatic to heavy
proteinuria.
Premature atherosclerosis is a major comorbid condition in
systemic lupus erythematosus, one of the SLE specific risk factors is
lupus nephritis, especially with impaired renal functions, also
antiphospholipid antibodies, low total white blood cell count and
lymphopenia were associated with atherosclerosis in SLE.
Carotid intima-media thickness (CIMT) measurement is a
noninvasive method to detect early subclinical atherosclerosis which
correlates with severity of coronary artery disease. So it is a reliable
tool for detecting early atherosclerosis in lupus nephritis patients.
Irisin is a myokine secreted by skeletal muscles in an exercise
dependent fashion as well as adipose tissue (subcutaneous adipose
tissue is more relevant than visceral adipose tissue). It is an antiatherogenic myokine promotes endothelial cells proliferation by
upregulating microRNA126-5p, irisin serve as a potential therapeutic
strategy to protect against atherosclerosis, after proteolytic cleavage
from the membrane protein fibronectin type III domain containing 5 (FNDC5). The expression of FNDC5 and subsequent irisin are
induced by exercise and peroxisome proliferator-activated receptor-γ
coactivator -1a (PGC-1a) in skeletal muscle.
We aimed to evaluate the possible correlation between irisin in
lupus nephritis female adults and CIMT as a biomarker for subclinical
atherosclerosis.
We included 110 subjects in the period from January 2020 to
August 2022, fifty-five subjects were sequentially selected from SLE
patients coming to the rheumatology and immunology outpatient
clinics and those who were admitted in inpatients wards of
rheumatology division, Internal medicine department at Menoufia
University Hospital and Mansoura university hospital, & fifty-five;
age and sex matched healthy controls were enrolled.
Full history, physical examination and investigations were
done and included CBC, creatinine, urinary protein creatinine ratio,
anti-DNA, lipid profile, carotid intima media thickness by doppler
ultrasound and irisin serum level was done using ELISA technique.
o Then our results were statistically analyzed and tabulated, we
found that; there was statistically significant positive correlation
between CIMT on one side and WBC, platelets count,
protein/creatinine ratio, Anti ds DNA titre, SLEDAI and LDL
on the other side.
o While negative correlation was detected with HDL and serum
irisin which was statistically significant.
o Regarding irisin serum level, it showed statistically significant
negative correlation with platelet count, Anti ds DNA titre,
SLEDAI and LDL, while statistically significant positive
correlation was detected with HDL.
o Univariate logistic regression showed that only serum irisin
level was the most important predictor of CIMT increment and
is independent risk factor for atherosclerosis.