الفهرس 
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Abstract
The human papilloma virus (HPV) is a 55-nm DNA virus that
belongs to the parvovirus family. it infects skin and mucosal
membranes and replicates in the nuclei of infected epithelial cells.
HPV consists of 70 distinct types, of which 34 are associated with
anogenital lesions.
Genital warts, are papillomata’s, pedunculated, or sessile
growths that can grow anywhere on anogenital skin. Single lesions are
usually 1 to 4 mm in diameter. Condylomata are usually flesh-colored,
but may be pigmented or erythematous. Intraepithelial neoplasia
occurs on the vulva, vagina, cervix, or penis. Bowenoid papulosis
occurs more frequently in hyperpigmented lesions and may be
interspersed with multiple condylomata. Progression to invasive
squamous cell carcinoma can occur, particularly in
immunosuppressed individuals. Large lesions are called giant
condylomata of Buschke and Löwenstein.
HPV is one of the most common sexually transmitted diseases in
the world, and anogenital warts are one of its various clinical
manifestations. It is estimated that between 3 and 4 million men
worldwide are diagnosed with genital warts each year. it is
transferred by skin-to-skin sexual contact and is accompanied with and
without clinical lesions.
Genital warts (GWs) are common among sexually active persons.
Although symptoms are in general mild, genital warts are
commonly perceived as a non-serious condition, treatment is often
long, of varying effectiveness and the recurrence rate is high, It has been
shown that anogenital warts influence psychological status, decreased emotional well-being has been reported among persons with genital
warts compared to persons without genital warts. Like many sexuallytransmitted infections (STIs) GWs were associated with a negative
impact on health-related quality of life.
Male patients with GWs have increased rates of anxiety,
depression and sexual dysfunction, Many people with genital warts
feel stigmatized by their condition, blame themselves, and worry that
the infection may be transmitted to a partner. They may also be
concerned that a new partner will reject them when they explain their
situation. Men who have multiple genital warts are more likely to
have higher rates of sexual dysfunction, depression, and anxiety.
It has been reported that patients with GWs have increased levels
of several cytokines such as tumor necrosis factor, interleukin 4 and
interleukin 10 that may induce anxiety in the brain.
The study was aiming to assess the potential impact of multiple
genital warts on the sexual function of men affected by such lesions.
This case control study included 40 male patients having multiple
genital warts. patients were collected from Dermatology and
Venereology clinic of Menoufia University Hospital, in addition to 40
healthy subjects of matched age and sex as controls.