الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Early prediction of cardiac complications in patients with type two diabetes mellitus by using various modalities of echocardiography are of great importance to improve the outcome of heart failure. Cardiac complications contribute as a major cause of morbidity and mortality in diabetic patients. Diabetes is a risk factor in 10-30% of patients who develop heart failure. In type two diabetes, isolated abnormalities of diastolic relaxation in the absence of symptoms or signs of heart disease suggest a diagnosis of diabetic cardiomyopathy. This is thought to result from micro angiopathy, deposition of collagen, decreased expression/activation of K+ channel and Na+ pump and decreased myofilament Ca2+sensitivity. Left ventricular diastolic dysfunction represents the earliest pre-clinical manifestation of diabetic cardiomyopathy, preceding systolic dysfunction and evolving to symptomatic heart. The prevalence of diastolic dysfunction increases with longer duration of diabetes. There was a linear progression of diastolic dysfunction with the increased age group. Thus, left ventricular diastolic dysfunction may represent the earliest stage of diabetic cardiomyopathy and timely diagnosis of this entity can be vital in the management of patients. The aim of the study was to determine the association between diastolic dysfunction and type two diabetes mellitus in asymptomatic patients by using various echocardiographic modalities to diagnose diastolic dysfunction in diabetic patients.