الفهرس 
MRI (Magnetic resonance imaging)Only 14 pages are availabe for public view
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Abstract
Iron oxide-based MRI contrast agents have been extensively analyzed in the past decade; however, they still need to be doped with biocompatible metals to enhance their potential and functionality as MRI contrast agents. Herein, we have synthesized and doped superparamagnetic magnetite nanoparticles (NPs) with magnesium (a bio-metal) and gadolinium (a T1 contrast agent) for use as contrast-negative nanoagents for T2 MRI. Four superparamagnetic compounds (Fe3O4, Mg0.1Fe2.9O4, Gd0.15Fe2.85O4, and Mg0.025Gd0.125Fe2.85O4) have been synthesized using the co-precipitation method. The physicochemical properties of the synthesized nanoparticles have been investigated by XRD, EDX, FT-IR, SEM, TEM, and VSM techniques. The cytotoxicity of the nanoparticles has been examined too. The T2 relaxivity parameters of NPs and their potential as MRI contrast agents have been investigated on phantom agarose at room temperature in a low B0 field, 1.5 Tesla in vitro. The results have revealed the formation of the pure phase and the composition of superparamagnetic nanoparticles with sizes ranging from 7 to 8.5 nm, showing good bioavailability. Field-dependent magnetization studies of the samples have confirmed the composition dependence of the magnetic properties and superparamagnetic behavior of the nanoparticles. In vitro MRI studies have showed good T2-weighted MR images, and the nanoparticles have shown transverse relaxivity values (r2) ranging from 0.281 to 0.678 mls-1mg-1 in a 1.5 T MR clinical scanner, confirming their potential as negatively T2 modal MRI contrast agents. Hence, doping of Mg and Gd promises to enhance magnetite nanoparticles as contrast nanoagents for MRI diagnostics.