الفهرس 
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Abstract
Background: Odontogenic tumors are a variety of benign and malignant lesions developed
exclusively on the jaws. They are known to have variable clinical behaviors and different
histological features. The development of odontogenic tumors possibly results from genetic defect
or some changes in biological molecules.
Aim: To assess the Glypican-3 immune expression in tumor cells of Ameloblastoma,
Ameloblastic Fibroma, and Ameloblastic Carcinoma, and correlate its relation with the known
biological behavior of these tumors. Also, we were studying nature and arrangement of collagen
fibers surrounding tumor cells using picrosirius red stain under polarized light microscope.
Methodology: 40 cases were selected from oral and maxillofacial pathology department
(ten cases in each group). Sections are prepared to be stained with H&E stain, Glypican-3 immune
stain and be examined under light microscope. Other sections are prepared to be stained with
picrosirius red stain and to be examined under polarized light microscope. Histomorphometric
analysis was done and measure area percents of Glypican-3 immune expression. Also, area percent
of red, yellow, and green color separately were calculated from picrosirius red stained sections by
image analyzer.
Results: level of expression of Glypican-3 is highly significant difference between the
groups. The level was highest in Ameloblastic carcinoma group followed by Ameloblastoma group,
then Ameloblastic fibroma and lowest in Dental follicle group. Regarding picrosirius red stain
results the ANOVA test revealed that the difference between the 4 groups in red, yellow, and green
color was highly statistically significant.
Conclusions: Glypican-3 immune expression is statistically significant difference among
study groups. which may play a role in their pathogenesis and is correlated with their biological
behaviors. Different color birefringence of collagen fibers surrounding odontogenic tumors revealed
the impact of types of collagens surrounding tumor on its biological behavior.
Keywords: Ameloblastoma,Ameloblastic,Fibroma,Ameloblastic carcinoma,Glypican-3,
picrosirius red.