الفهرس 
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Abstract
Odontogenic tumours (OT) are a diverse group of lesions that range from hamartomatous lesions to malignancy in terms of their histopathologic traits and clinical behaviour. OT are made from the ectomesenchymal and/or epithelial tissues of the tooth-forming apparatus. Odontogenic tumours are the product of inductive interactions between odontogenic ectomesenchyme and epithelium, much as normal odontogenesis.
In this study, we identified the proteins claudin-1 and -catenin in odontogenic tumours using immunohistochemistry and linked their expression on odontogenic tumours. 46 formalin-fixed, paraffin-embedded samples that had previously been identified as odontogenic tumours were used in this study. The patient’s age, gender, tumour type, location, size, and outward look were all included in the clinical records. border of the tumour and recurrence. The samples were obtained between 2016 and 2019 from the South Egypt Cancer Institute’s (SECI), Assiut University’s, Oncologic Pathology Department.
Ameloblastoma, which was discovered in 30 cases, was the most prevalent kind in the current study, followed by odontogenic fibromyxoma and calcifying epithelial odontogenic tumour, which were found in 5 cases and 4 cases, respectively. Two patients had an adenomatoid odontogenic tumour, two had an ameloblastic carcinoma, two had an ameloblastic fibroma, and one had an ameloblastic fibrosarcoma. The acquired samples were periodically stained with H&E stain and serially cut into sections that were about 5 um thick for re-evaluation of the diagnosis.
Ameloblastoma and adenomatoid odontogenic tumours were both related with -catenin cytoplasmic expression (p=0.000). However, cytoplasmic -catenin expression was minimal in all ameloblastic fibroma and ameloblastic fibrosarcoma cases, compared to all ameloblastoma instances. Age, gender, location, gross, and tumour boundaries were other clinicopathological variables that did not significantly correlate with -catenin.
Ameloblastoma, calcifying epithelial odontogenic tumour, adenomatoid odontogenic tumour, and ameloblastic cancer were odontogenic tumour types related with high claudin-1 percentage scores (p=0.013). About 56.7% of all instances of calcifying epithelial odontogenic tumour, adenomatoid odontogenic tumour, and ameloblastic cancer had high claudin-1 percentage scores.
Additionally, there was a significant correlation between the kind of tumour and the expression of the claudin-1 percentage score (p=0.023).
Low claudin-1 expression percentage score and non-infiltrative tumour boundaries were significantly correlated (p=0.029). In 77% of non-infiltrative tumours, claudin-1 expression was found to be low.
Other clinicopathological characteristics (age, gender, location, and size) did not significantly affect the connection between claudin and any of them.
The relationship between the level of Claudin1 and -catenin cytoplasmic expression was weak (p=0.000, r=0.0586). There was a weakly positive correlation between Claudin1 intensity and Claudin1 percentage (p=0.000, r=0.0535).
Claudin1 % and -catenin cytoplasmic expression did not significantly correlate.
Poor recurrence-free survival was associated with both the maxillary location (p=0.000) and infiltrative tumour border (p=0.000) of the cancer.
Age, gender, -catenin expression, or even gross expression, had no discernible effects on recurrence-free survival.