الفهرس 
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Abstract
Several methods, including urethral dilation, direct vision internal urethrotomy, and laser urethrotomy and urethroplasty are used for management of urethral stricture disease.
Many researchers suggested using laser urethrotomy as an alternative to cold knife urethrotomy as it was associated with erectile dysfunction, extravasation, urinary retention, haematuria, and recurrence.
The main advantage of Ho: YAG laser that it provides ablation energy with adequate hemostasis. In addition, it causes minimal damage to the surrounding structures due to the minimal penetration depth of 0.4 mm so it has lower complication rate than cold knife urethrotomy.
This is prospective randomized clinical trial study that was conducted at Ain Shams University hospitals and Nile hospital, and included 30 patients were assigned into two equal groups using simple randomization.
group A included 15 patients which underwent urethrotomy using cold knife, also group B included 15 patients underwent urethrotomy using Holmium laser.
Both groups had 18 fr catheter after urethrotomy then removed after 7 days, and they were followed after 1and 3 months at outpatient clinic using uroflowmetry and ACUG.
Both groups were well-matched as regards base line data including age and cases of stricture.
In our study we found that Holmium laser urethrotomy was significantly better than cold-knife urethrotomy as regards PVRU and IPSS score, yet there was no significant difference as regards PFR after 1 and 3 months postoperative.
The time of operation was shorter in laser urethrotomy group compared to time at cold knife group.
There was insignificant difference between both groups as regards complications including Hemoglobin drop, extravasation and recurrence.
Finally both techniques are effective, easy to perform, low invasive and safe with better success rate using the Holmium laser.