الفهرس 
Aim of The WorkOnly 14 pages are availabe for public view
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Abstract
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Summary
Seborrheic dermatitis (SD) is a chronic and recurrent inflammatory skin disease that affects body areas rich in sebaceous glands.
The worldwide prevalence of seborrheic dermatitis is around 5%, but the prevalence of its non-inflammatory variant, dandruff, is probably closer to 50%. Despite the high prevalence, the pathogenesis of SD is not well understood. There are three main etiological factors associated with its development: presence of Malassezia spp., sebaceous gland secretion and the individual susceptibility. interactions between these factors play a pathogenetic role in SD.
Vitamin D is the vitamin that controls calcium absorption and bones calcification. It has been well known for decades that its deficiency causes rickets in children and osteoporosis in adults.
Low serum levels of 25(OH)D are associated with multiple immune-related diseases including autoimmune disorders and infectious diseases Such as psoriasis, type 1 diabetes, multiple sclerosis, sepsis and Inflammatory Bowel Diseases.
Regarding available informations there were no studies to assess vitamin D status in patients with seborrheic dermatitis in our region. which encouraged us to do this research to study the level of vitamin D in patients with seborrheic dermatitis and its relationship as a disease compared to healthy people.
This study was held at Department of Dermatology, Andrology & STDs, Faculty of Medicine, Menoufia University. Patients were conducted on two groups patient group and control group. Patients group included 35 patients with SD and the second group is a control group of 35 volunteers who do not suffer from SD and who match with patients in age, sex, body mass index and daily exposure to sunlight. We excluded patients under
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medical treatment or patients suffering from diseases that may affect the level of vitamin D in the blood.
The patient’s total history, clinical examination, onset, course, duration of the disease, family history of SD and severity of the disease using SDASI and SDSS scores were recorded and the following data were verified for all patients and control group, age, sex, BMI, skin phototype and sun exposure history.
A venous blood sample (3ml) was withdrawn from each subject participating in this study.
The level of vitamin D was measured in both groups (patients and control group) using ELISA. The final results were compared between SD patients and control group. There was also a correlation between vitamin D and SD severity represented by SDASI and SDSS scores.
After the collected data was analyzed using needed statistical methods and after being presented in tables and charts, it was clear from the results that serum vitamin D was significantly lower in patients with seborrheic dermatitis compared to the control group. It was also found that statistically significant negative correlation exists between the level of vitamin D in the blood and the severity of facial SD. However, there was no significant correlation between serum vitamin D level and severity of scalp involvement.
from this study we conclude that Serum 25(OH)D levels were significantly lower in seborrheic dermatitis patients than in healthy control subjects. These data support that vitamin D deficiency may has a role in the development of seborrheic dermatitis. Finally, the main limitation of this study is the small number of patients, so we recommend a study of greater number of patients to furthermore study the relationship of vitamin D in SD and the possibility of using vitamin D as a primary or complementary treatment for this disease.