الفهرس 
Clinical Aspects of chronic Obstructive Pulmonary DiseaseOnly 14 pages are availabe for public view
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Abstract
COPD is characterized by the presence of airflow limitation and chronic airway inflammation. During AE-COPD more airway obstruction and systemic inflammation are observed, which in turn are responsible for worsening of clinical symptoms, reduction of lung functions, increased hospitalization, and rate of admission to intensive care unit and need for more intense treatments.
NLR and CRP are biomarkers of inflammation and are estimated from routine investigations done at hospital admission. NLR in peripheral blood, have been reported to be increased in AE-COPD compared to stable state.
The aim of this study was to clarify the role of NLR as inflammatory marker in AE-COPD and correlation with other inflammatory markers as CRP.
This study was a prospective observational study on 100 patients with AE-COPD, 50 patients with stable COPD and 50 matched healthy persons as control subjects. Complete blood cell count, C-reactive protein, sputum culture and sensitivity and pulmonary function tests for those patients and the control were done. Patients were attendants of outpatient chest clinic of Menoufia university hospitals in the period from 2021 to December 2022 and 50 healthy persons were included as a control group. Informed consent was taken from all subjects and approval of ethical committee of Menoufia university was taken. IRB approval number and date 7/2020 CHES.
Patients were diagnosed as COPD based on history, clinical examination, and presence of a post-bronchodilator FEV1/FVC ratio <70% in spirometry.
Exclusion criteria were patients less than 18 years old, pregnant females, acute cerebro-vascular event, acute coronary syndrome, hematological diseases, inflammatory bowel disease, rheumatological diseases, liver diseases, renal diseases, and thrombocytopenia.
All subjects under the study were subjected to full history taking, clinical examination, and radiological investigation in the form of chest x-ray postero-anterior and lateral views and spirometry in the form of FVC, FEV1, FEV1/FVC, and PEFR, forced expiratory flow (FEF 25-75)
Blood sample (3ml) was collected in a clean plastic tube containing Ethylene diamine tetra-acetic acid (EDTA tube), Complete blood cell count with differential count of white blood cells was done.
Blood sample (3ml) was collected in a clean dry plastic tube for CRP.
A sputum sample into a specimen container was obtained from each patient for sputum culture and sensitivity.
This prospective study was conducted on 100 patients with AECOPD with a mean age of 49.67±7.608 years, 50 patients with stable COPD with a mean age 48.0±4.522 years, 50 healthy controls with mean age 49.18±8.253. two thirds of patients were males and one third were females. There were no significant statistical differences between the study groups regarding age and sex.