الفهرس 
Introduction .Only 14 pages are availabe for public view
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Abstract
Within the limitations of the present study, it was found that:
1. Intraoral cryotherapy application for 30 minutes with 3 applications (10 minutes each) using ice gel in a plastic cover customized for patients reduced postoperative pain levels following single-visit root canal treatment in single-rooted premolar teeth diagnosed with irreversible pulpitis with symptomatic apical periodontitis .
2. Intraoral cryotherapy reduced Substance P levels but with no significant difference between cryotherapy and control group.
3. There was a moderate positive significant correlation between Substance P level and post operative pain.