الفهرس 
VITAMIN D METABOLISMOnly 14 pages are availabe for public view
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Abstract
Abstract:
Background: Vitamin D is a steroid based hormone that has crucial role in calcium metabolism and bone homeostasis and potential role in fibrosis including liver. Patients with chronic liver disease has tendency for vitamin D deficiency with possible sequalae including hepatic osteodystrophy.
Safe and effective regime of vitamin D that can be used in children with chronic liver disease is still not well established. Moreover, the potentiality of reversing fibrosis process or halting it by correction of vitamin D is still not well studied.
Aim of work: The primary aim of the study is to assess the efficacy and safety of vitamin D regime using two different mode of administration. In addition, assess the possible antifibrotic effect of vitamin D therapy by assessment of fibroscan.
Methodology:
Twenty four children with different etiologies of chronic liver disease but age and sex matched as well as anthropometric measures are enrolled in the study. They were distributed randomly among the two arms of the study and followed up for 6 months using different laboratory and imaging variables. The two regimes were group A which is stoss 200.000 vitamin D therapy while group B was oral vitamin D therapy. All children received maintenance vitamin D and Ca doses thereafter for the whole follow up period.
Results:
There were significant improvement of vitamin D level in both arms with no development of toxic s/o of vitamin D toxicity. The difference of improvements between both arms were not significant display the equal efficacy of both regimes. There were no significant improvement of fibroscan parameters following vitamin D treatment in either group.
Conclusion:
Stoss and oral vitamin D regimes suggested in the study are both equally effective and safe in the treatment of vitamin D deficiency among children with chronic liver disease. Despite no proof of antifibrotic effect upon vitamin D correction, further study is required to evaluate this issue