الفهرس 
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Abstract
Aim of the study: To study the effect of Licochalcone A on cell viability, cell proliferation and
apoptosis compared to Paclitaxel in cultured OSCC cell line (SCC-15) and to determine the role of
Licochalcone A in enhancing the anti-proliferative and apoptosis inducing effects of Paclitaxel.
Methodology: The cultured squamous cell carcinoma cell line (SCC-15) was obtained and divided
into three treatment groups: Licochalcone A treated group, Paclitaxel treated group, combined drugs
treatment group (Licochalcone A + Paclitaxel) and untreated control group. All groups were
submitted to cell viability test, immunofluorescence assessment, and immunohistochemical study.
Results: Our findings revealed that cell viability in Licochalcone A and Paclitaxel treatment groups
was decreased in a concentration and time-dependent manner compared to the control group. For
immunohistochemical findings, the untreated control group of SCC-15 cells showed the highest
area percent for IPO-38 immunoexpression while the area percent for IPO-38 decreased in the
Licochalcone A group. The Paclitaxel and combination groups of SCC-15 cells showed the lowest
area percent of IPO-38 immunoexpression. Regarding the fluorescence microscopic findings,
Annexin V immunofluorescence levels showed the highest values in the combination group
followed by Paclitaxel group then LCA group, while the control group showed the least levels.
Conclusion: Licochalcone A enhanced the effect of Paclitaxel on reducing cell proliferation and
inducing apoptosis in (SCC-15) cell line.
Keywords: LCA: Licochalcone A,PTX: Paclitaxel,SCC-15: squamous cell carcinoma-15.