الفهرس 
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Abstract
2 diabetes mellitus is a widespread chronic metabolic disorder characterized by hyperglycemia and associated with several complications such as hyperlipidemia. Aim: the present study aimed to evaluate the anti-diabetic efficacy of pomegranate peel extract and L-carnitine on streptozotocin-induced diabetes mellitus in rats. Rats (n=70) were divided into seven groups, consisting of a maximum of ten rats each, as follows group (1)normal rats were given a standard diet, group (2)normal rats were given PPE 200mg/kg per day over the course of 12 weeks , group (3)normal rats were given L-carnitine 100 mg/kg per day over the course of 12 weeks , group (4)diabetic control (rats were given a high-fat diet to cause hyperlipidemia, and rats were given streptozotocin to cause type II diabetes) , group (5)diabetic rats received PPE 200mg/kg orally every day for 12 weeks , group (6)diabetic rats received Lcarnitine 100 mg/kg orally every day for 12 weeks , group (7)diabetic rats received PPE 200mg/kg and L-carnitine 100mg/kg orally every day for 12 weeks, respectively. Various parameters were studied and the treatment group with the PPE and L-carnitine showed a significant decrease in blood glucose and serum marker enzyme levels. The total cholesterol and serum triglycerides levels, low density lipoprotein, and very low density lipoprotein were also significantly reduced and the high density lipoprotein level was significantly increased upon treatment with the PPE and L-carnitine. A significant increase in the levels of superoxide dismutase(SOD) and catalase (CAT) and decrease in the of malondialdehyde (MDA) were observed in PPE and L-carnitine treated diabetic rats. Thus, from this study we conclude PPE and L-carnitine exhibited significant antihyperglycemic, hypolipidemic, and antioxidant activities in streptozotocin induced diabetic rats after treatment for 12 weeks.