الفهرس 
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Abstract
The adsorption of doxorubicin (DOX), as anticancer drug, onto a microwave synthesized and loaded graphene oxide with 3-aminopropyltrimethoxysilane for the formation a target drug nanocarrier (GO@3- APTMSi) was explored and investigated. GO@3-APTMSi was simply synthesized according to a facile microwave-assisted synthesis via irradiation heating. The particle size of GO@3-APTMSi nanocarrier was confirmed in the range 16.43-31.06 nm as determined by the TEM analysis. Other instrumental techniques as FT-IR, SEM/EDX, XRD zeta and potential were implemented for the aim of structural and morphological characterizations. The doxorubicin (DOX) loading capacity on the surface of GO@3- APTMSi was confirmed as 92.6%. The DOX drug binding process was established and interpreted on the basis of strong Schiff’s base formation reaction between the carbonyl group in DOX molecule with the loaded amino groups on GO@3-APTMSi as well as hydrogen bonding and π-π stacking mechanisms.