الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Non-ST elevation myocardial infarction (NSTEMI) is one of the leading causes of mortality and morbidity worldwide. Diabetes mellitus is a disease of metabolic dysregulation, most notably abnormal glucose metabolism, accompanied by characteristic long- term complications. The complications that are specific to diabetes include retinopathy, neuropathy. Patients with all forms of diabetes of sufficient duration, including insulin- dependent diabetes mellitus (IDDM) and non-insulin dependent diabetes mellitus (NIDDM), are vulnerable to these complications which cause serious morbidity. Most of the patient undergoing coronary revascularization are diabetic due to progression of atherosclerosis. Diabetic patients with non-ST elevated myocardial infarction acute coronary syndrome are at risk for subsequent cardiovascular events. Transthoracic 2D echocardiography is a modality for assessment left ventricular function before and after percutaneous intervention between diabetic and non-diabetic patients. Recently it has been demonstrated that speckle tracking echocardiography provides more information that allows non-invasive measurement of allover LV strain and twist. This study aimed to compare left ventricular systolic function by 2D and speckle tracking echocardiography between diabetic and non-diabetic patients undergoing percutaneous intervention in non-ST- elevated myocardial infarction. This prospective randomized clinical study was conducted on 100 patients with acute non-ST elevation myocardial infarction to compare left ventricular systolic function by 2D and speckle tracking echocardiography between diabetic and non-diabetic patients undergoing Percutaneous intervention. Patients were randomly allocated to two groups; group I: 50 diabetic patients with acute NSTEMI, group II: 50 non-diabetic patients with acute NSTEMI. All patients in the study were subjected to full history taking, complete clinical examination, laboratory investigations (cardiac enzymes, lipid profile, fasting blood sugar), electrocardiogram, echocardiography: 2D and speckle tracking echocardiography were done before and after percutaneous angiography. Summary of our Results: • There was no significant difference in baseline characteristics (age, gender, and height) and in vital signs (SBP, DBP, and HR) between the studied groups however, weight and BMI were significantly higher in diabetic group compared to non-diabetic group (p <0.001). • Total cholesterol and LDL were significantly higher in in diabetic group compared to non-diabetic group, but there was no significant difference in HDL and triglycerides between the studied groups. • RBG was significantly higher in in diabetic group compared to non-diabetic group. • Regarding 2D echocardiography data in the studied groups; there was no significant difference in ejection fraction (EF) on admission however, after 3 months EF was significantly higher in non-diabetic group compared to diabetic group (p =0.005). • There was no significant difference in LVESV on admission however, LVESV after 3 months was significantly higher in diabetic group compared to non-diabetic group (p =0.013 and 0.002 respectively). • LVidS on admission was significantly higher in diabetic group compared to non-diabetic group however, there was no significant difference in LVidS after 3 months. • There was no significant difference in FS on admission and after 3 months between diabetic group and non-diabetic group. • EF and FS were significantly increased after 3 months compared to EF and FS on admission in in diabetic and non-diabetic groups, But LVESV and LVidS after 3 months were significantly decreased after 3 months compared to LVESV and LVidS on admission in both groups. • Global longitudinal strain (GLS) on admission was significantly lower in non-diabetic group compared to diabetic group (p =0.037) but there was no significant difference in GLS after 3 months between the studied groups. • GLS was significantly decreased after 3 months compared to on admission readings in diabetic and non-diabetic groups.