الفهرس 
ALLERGY IN CHILDRENOnly 14 pages are availabe for public view
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Abstract
ABSTRACT
Introduction: The association between urinary tract abnormalities and allergic diseases was previously studied, but the coincidence of allergy flare ups with urological manifestations was seldomly discussed.
Aim of work: To assess the presence of urological manifestations in paediatric patients with various types of allergies, and to determine the change in urological manifestations with allergic disease activity.
Methods: A cross sectional pilot study with nested follow up, was conducted in the Allergy, Immunology and Rheumatology Clinic, Children’s Hospital, Ain Shams University over 6 months duration from March 2022 to September 2022. Patients diagnosed as allergy were recruited consecutively during their routine follow up visits. All patients were screened at time of allergy flare up for urological symptoms, and 50 patients of those associated with urological symptoms were investigated at time of enrolment and followed up at remission. Investigations included urine analysis, urinary eosinophils and urinary eosinophilic cationic protein (ECP).
Results: Among 193 allergic children, 50 patients, aged 8.04 ± 2.97 years old, 28 (56%) boys and 22 (44%) girls, developed urological symptoms at time of allergy exacerbation (31.6%), 38% of them had combined forms of allergy. Statistically significant decline of the urological manifestations was found by time of allergy remission, on allergy controller therapies. Eosinophils were microscopically detectable in the urine of 18 (36%) of the studied patients during allergy flare up, and not detected in any patient by remission. Urinary ECP median level was significantly higher at exacerbation than allergy convalescence.
Conclusion: Urological manifestations are common association with allergy flare ups, regardless the type of allergy. Presence of urinary eosinophils and elevated levels of urinary ECP at times of allergy flare ups suggest that the urinary system could be targeted by allergens, which needs more elucidation in further studies. The study was limited by the lack of control group.