الفهرس 
Introduction and The aim of the workOnly 14 pages are availabe for public view
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Abstract
Cancer remains a significant global health challenge, necessitating the exploration of new therapeutic approaches. Ehrlich Ascites Carcinoma (EAC) provides a well-established model for studying tumor growth and potential treatments. This study focuses on investigating the efficacy of specific heterocyclic compounds in combating EAC growth in mice. Heterocyclic compounds, characterized by ring structures containing heteroatoms, have shown diverse biological activities, including anticancer properties. The goal is to assess the selected compounds’ effects on tumor growth, metastasis, and overall survival using a murine EAC model. Additionally, the study aims to uncover the compounds’ mechanisms of action, such as their impact on cell proliferation, apoptosis, and antioxidant state. Positive outcomes could lead to the development of novel cancer therapies. The findings may provide insights into molecular pathways and potential targets for future.
To study the antitumor activities of the complex on EAC bearing mice, animal randomly divided into nine groups of ten mice each. Group1 of ten healthy mice that wasn’t injected with any solution served as negative control group.Group2 of ten mice injected (I.P) with( 2.5 106 EAC cells/0.2ml/mouse) only served as positive control group . Group3 of ten mice injected (I.p) with EAC(2.5 10^6 cells/0.2 ml/mouse)once in the first day then injected (I.P) with 5-flurouracil of dose (51mg/kg) for one time served as standard drug group (EAC+5-flurouracil).group 4,5,6 of ten mice each injected (I.p) with EAC (2.5 10^6 cells/0.2 ml/mouse) once in the first day then injected (I.P) with the freshly prepared N2 of doses (50,75,100 mg/kg) 5 times for ten days (day after day) .group 7 of ten mice injected (I.p) with EAC(2.5 10^6 cells/0.2 ml/mouse)once in the first day then injected (I.P) with the combination of the freshly prepared N2 (100mg/kg) and 5-flurouracil (51mg/kg) 5times for ten days (day after day). group 8 of ten healthy mice injected (I.P) only with the freshly prepared N2 of dose (100mg/kg) 5 times for ten days (day after day). group 9 of ten healthy mice injected (I.P) with solvent (DMSO) 5 times for ten days (day after day).
In conclusion, Our study results show that the newly synthesized hybrid N2 has been considered as anticancer drug against Growth of Ehrlish Ascite Carcinoma in Mice.