الفهرس 
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Abstract
SUMMARY
V
itiligo is a common, asymptomatic, acquired depigmentation disorder, clinically characterized by milky white sharply demarcated, macules and patches that are scattered symmetrically or asymmetrically over the body causing severe cosmetic distress and social stigma.
It can be classified as nonsegmental, segmental, mixed, or unclassified. In vitiligo, melanocytes are targeted by multiple aggressions leading to marked reduction and destruction of pigment cells, including autoimmune process, altered cellular environment, defective melanocytes migration, stress, and genetic factors.
The aim of this study was to evaluate the efficacy of Platelet Rich Plasma, Microneedling and combined PRP and Microneedling in treatment of stable non segmental vitiligo.
This prospective randomized clinical study was conducted in the period from Novamber 2020 to May 2022 . Patients were recruited from outpatient clinic of dermatology of Ain Shams University Hospital.
This study included 225 lesions classified to three groups, first group received PRP sessions only, second group received microneedling sessions only and third one received combined PRP& microneedling sessions. each group received 6 sessions with 2 weeks interval for 3 months .
A significant reduction in the Vitiligo was demonstrated by Computer Assisted Grid ”VACAG” in the group of microneedling followed by the combined microneedling and PRP group. The least improvement was in the PRP group.
There were minimal side effects like pain and erythema during and shortly after sessions.
Regardless of the modalities, the better improvement was observed in the neck followed by the trunk then lower limp and the most resistant site was the upper limp