الفهرس | Only 14 pages are availabe for public view |
Abstract Summary Psoriasis is a chronic inflammatory skin disease with a strong genetic predisposition and autoimmune pathogenic traits. The worldwide prevalence is about 2%, but varies according to regions. The hallmark of psoriasis is sustained inflammation that leads to uncontrolled keratinocyte proliferation and dysfunctional differentiation. Disturbances in the innate and adaptive cutaneous immune responses are responsible for the development and sustainment of psoriatic inflammation MicroRNAs are small non-coding RNA molecules involved in RNA-silencing and the post-transcriptional regulation of gene expression, which also appear to mediate the immune dysfunction in psoriasis. MiR-195 belongs to the miR-15/16/195/424/497 miRNA family, which is closely related to cell propagation and apoptosis The TGF-β signaling pathway governs key cellular processes under physiologic conditions and is deregulated in many pathologies, including cancer. TGF-β is a multifunctional cytokine that acts in a cell- and context-dependent manner as a tumor promoter or tumor suppressor. This current work was done to explain the role ofMiR-195 in the pathogenesis of Psoriasis vulgaris and to identify its correlation with disease severity. The study included 30 psoriatic patients, and 30 healthy volunteers serving as control group. The results of the present study showed noteworthy difference between cases & controls as regards MiR-195. Finally, the present study fulfilled that MiR-195 may have an essential task in the pathogenesis of psoriasis. |