الفهرس 
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Abstract
Two acridine Schiff base ligand derivatives; 1,1’-(acridine-3,6-diylbis(azaneylylidene))bis(methaneylylidene))bis(naphthalen-2-ol); L1 and N,N’-(acridine-3,6-diyl)bis(1-(quinolin-2-yl)methanimine); L2, were prepared by 1:2 condensation reaction of 3,6-diaminoacridine hydrochloride with 2-hydroxynaphtaldehyde and 2-Quinolinecarboxaldehyde, respectively. Thermal refluxing reactions of group VIB metal carbonyls ((M(CO)6) M= Cr, Mo, and W) with Schiff base ligands resulted in the synthesis of [Cr(L1)(O)2(DMF)](1), [Mo(L1)(O)3(DMF)](2), [W(L1)(O)3(DMF)](3), [Cr(L2)(O)2(DMF)](4), [Mo(L2)(O)3(DMF)](5), and [W(L2)(O)3(DMF)](6).
All formed compounds were characterized by several analytical and spectroscopic analysis such as Elemental analysis, infrared spectroscopy, mass spectrometry, 1H NMR, thermal analysis (TGA), magnetic measurements.
Furthermore, ligand one was analyzed by X-ray crystallography. The L1 molecule crystallised in a monoclinic crystal system with a space group P21/c, according to the X-ray single crystal analysis. The crystallisation of the compound included five water molecules. It’s interesting to note that L1 formed as a double zwitterion when the H+ of hydroxynaphthalene’s OH group moved to the nitrogen of the azomethine to produce NH+ and O moieties, with hydrogen bonding occurring between them. Additionally, the L1’s Hirshfeld surface analysis was examined.
The studies showed that the formed Schiff base existed as tetradentate ligand but bonded to metals through two positions only. Also, the analysis revealed that all complexes appeared as oxo complexes and DMF which used as a solvent, bonded to the central metal ion.
Biological activity including antimicrobial and antioxidant activities of all compounds was investigated. In addition to, DNA binding including UV-vis absorption titrations, fluorescence quenching investigations, and viscosity evaluations was carried out. It was
determined that the binding interaction with DNA was electrostatic binding mode rather than intercalative mode. The molecular docking of the compounds was also investigated with three large molecule receptors (PDB: 4BJP, 1BQB, and 1BNA). These targets were selected to compare the experimental biological data with the results of the docking analysis.