الفهرس 
Aim of the workOnly 14 pages are availabe for public view
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Abstract
Thiosemicarbazones have attracted considerable attention by chemists and biologists because of their wide range of pharmacological effects such as antibacterial, antiviral, particularly antitumor and antileukemic activities. It well known that thiosemicarbazones coordinate as bidentate ligands through azomethine nitrogen and thione/thiolate sulfur.
The general scope of this thesis is to prepare, characterize, tested as safe candidates against covid-19, antibacterial and antifungal of some mono- and divalent transition metal ion thiosemicarbazides, thiosemicarbazones or thiocarbohydrazone complexes.
A brief description of the different chapters in the thesis is given as follows:
I- The first chapter presents a literature survey on the previous work carried out on:
i- Synthesis of thiosemicarbazides, thiocarbohydrazides and thiosemicarbazones
ii- Synthesized transition metal complexes of thiosemicarbazides, thiocarbohydrazides and
thiosemicarbazones
iii- Biological activity of the synthesized thiosemicarbazones ligand and their transition metal
complexes
II- The second chapter includes the results and discussion of the obtained data.
This chapter (II) is divided into three main parts:
Results obtained regarding the first part of chapter (II) can be summarized as follows:
Metal complexes of thiosemicarbazones derived by 2-quinolones with Cu(I), Cu(II) and Ni(II); Identification by NMR, IR, ESI mass spectra and in silico approach as potential tools against
SARS-CoV-19
Preparation of quiolynyl thiosemicarbazone ligands 149a-f
The synthesized ligands announced as quinolynyl thiosemicarbazones 149a-f were obtained in 65-80% yield via refluxing of thiosemicarbazide (11a) with the appropriate aldehydes 148a-f by refluxing in EtOH and glacial acetic acid (1: 1) for 6-8 h as shown in Scheme 68.