الفهرس 
INTRODUCTION & AIM OF THE WORKOnly 14 pages are availabe for public view
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Abstract
Background: Chlorpyrifos (CPF), is a widely used organophosphate (OP) insecticide. OP exposure increases the risk of cognitive and memory dysfunction such as Alzheimer’s disease (AD). Recently, the role of dysregulation of brain cholesterol metabolism in the development of AD and neurodegenerative disorders is being intensively investigated. Dysregulation of cholesterol metabolism affects amyloid β (Aβ) production and clearance, tau phosphorylation, neuroinflammation, and oxidative stress.
Aim: In this study, we focused on the role of cholesterol metabolism dysregulation in neurotoxicity induced by CPF while observing the potential protective effect of coenzyme Q10 (CoQ10) which is a component of the mitochondrial chain known to have antioxidant and anti-inflammatory effects.
Further to illustrate if its role related to correcting the disturbed brain cholesterol metabolism.
Methods: Thirty-two male Wistar rats were divided into four groups (8 rats each). The effect of CoQ10 on behavioral changes, cholesterol metabolism, oxidative stress, and inflammatory markers, as well as hippocampal histological changes, were investigated.
Results: CoQ10 significantly ameliorated the CPF-induced behavioral impairment assessed by novel object recognition, Y maze, and open field tests. It improved dysregulation of cholesterol metabolism by decreasing brain total cholesterol through increasing ATP binding Cassette Transporter A1 (ABCA1). In addition, it improved oxidative stress and neuroinflammation reflected by increasing glutathione and decreasing malondialdehyde, tumor necrosis factor-α Moreover, it improved phosphorylated tau (P-tau) level, hippocampal histopathological changes, and Aβ deposition.
Conclusion: Our findings revealed that CoQ10, in addition to its antioxidant, anti-inflammatory, and neuroprotective characteristics, also ameliorated the dysregulated brain cholesterol metabolism found in CPF-induced neurotoxicity.
As a result, this study brought attention to CoQ10’s potential to counteract the negative effects of CPF exposure.