الفهرس 
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Abstract
Three experiments were conducted during the period from February 2021 to January2022 in the Laboratory Animal Unit of Pharmacology Department, Faculty of Pharmacy, British University in Egypt. The first experiment was Behavioral and Biochemical Performance of Swiss and Balb/C Mice Exposed to Multiple Concurrent Acute Stress MAS, A total number of fourteen adult males of each strain, were housed in either the control group or the multiple concurrent acute stress (MAS) groups that was exposed to stressors for 3-hours. Serum corticosterone level, brain levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), malondialdehyde (MDA), and glutathione (GSH) were measured. Mice were subjected to open field, plus maze, and dark light activity box tests. Swiss Multiple Acute concurrent Stress group (SMAS) showed more responsiveness to MAS than Balb/c Multiple Acute concurrent Stress (BMAS) in most biochemical and behavioral parameters, with an elevated level of corticosterone and MDA, IL-6, and TNF-αand reduced levels of GSH. In conclusion, SMAS showed a more effective response to MAS than BMAS, making them a selection model in stress research. The second experiment was welfare enhancement of mice model of ehrlich ascites carcinoma (EAC) in 56 female of two strains Balb/c and Swiss albino including the individual and group caging with or without enrichment. Glucose blood level, amount of ascites fluid and frequency of escape, mortality rate, ascetic volume, number of live cells and pain assessment were measured. Mice were displayed to open field, plus-maze tests. The results were recorded the highest in the physiological and behavioral parameters with the least mortality rate in the Balb/c mice specially GTNE and ITE groups. In conclusion, the Balb/c is the best model of EAC that can tolerate pain and adapts most kinds of housing methods. The third experiment was effect of individual caging and enrichment on behavioral and physiological performance in Balb/c and Swiss mice in 56 female of both strains Balb/c and Swiss albino including the individual and group caging with or without enrichment. Mice were subjected to open field, plus maze. Glucose blood level and escaping rate was calculated. The results were recorded and the grouped caged with or without enrichment, mice had high exploration rate and locomotors activity specially the Balb/c mice, while the individual caging without enrichment was stressed and have escaping behavior from the depressed isolated caging and the failure to adapt with the situation in both strains. And the individual caged with enrichments were stressed with self-satisfaction leads to depression and low locomotive activity and low social interaction.