الفهرس 
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Abstract
Summary
Cellulite is traditionally considered a highly prevalent aesthetic condition in women. from a clinical standpoint, it is characterized by a cottage-cheese-like appearance of the skin, which can be most commonly found in certain areas of the lower body. This study was conducted at Beni-Suef University Hospital on females to assess the adiponectin level and adiponectin gene expression in cases with cellulite.
Adiponectin is a hormone produced by adipose tissue which influences metabolism, endothelial function, inflammation and extracellular matrix deposition. The endocrine function of adiponectin can affect subcutaneous vascularization, which is the pathophysiology of cellulite.
The aim of this thesis is to measure the level of adiponectin in blood in women with and without cellulite, also comparing the levels of gene expression of adiponectin in blood of women with cellulite and women without cellulite.
This study is Case control study, was carried out on 60 patients at Dermatology Outpatient Clinic at Beni-Suef University Hospital. The main findings of this study was:
The mean age of females with cellulite was 27.3±7.5 with no significant differences between cases and controls.
A significant higher BMI was observed in cases of cellulitis (23.9±1.2) than controls (22.6±2.3).
There was an insignificant difference between cases of cellulitis and controls regarding their Adiponectin hormone level. The median level of adiponectin hormone for cases with cellulite was 7 mg/dl and for controls was 6.8 mg/dl.
Adiponectin gene expression was significantly decreased in cases with cellulite (0.6) compared to controls (1.8).
There was no significant role of adiponectin hormone in prediction of cellulitis but the adiponectin gene expression had a significant role with fair sensitivity and specificity.
The mean HDL in cases with cellulite was 50±8.8 mg/dl compared to 49.5±6.5 mg/dl for controls with no significant differences.
The mean LDL in cases with cellulite 115.7±20.9 mg/dl and was 114.5±22.1 mg/dl for controls with no significant differences.
The mean cholesterol level was 170.6±35.2 mg/dl for cases with cellulite and 164.4±44.2 mg/dl for controls with no significant differences.
The mean triglycerides level was 119.1±19.6 mg/dl for cases with cellulite and 115.6±24.1 mg/dl for controls with no significant differences.
There was a significant positive linear correlation between Adiponectin hormone and HDL in cases and controls.
There was a significant negative linear correlation between Adiponectin hormone and LDL, cholesterol and triglycerides in cases and controls.
There was no significant correlation between gene expression and all parameters of lipid profile.