الفهرس 
KIDNEY FIBROSISOnly 14 pages are availabe for public view
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Abstract
ABSTRACT
Background: Hepatocellular carcinoma (HCC) is a significant global health concern, ranking as the sixth most common cancer worldwide. In Egypt, it is the fourth most prevalent malignancy. The rising incidence of HCC has been attributed to advancements in screening programs, improved diagnostic tools, increased survival rates in cirrhotic patients, and a higher prevalence of hepatitis C virus (HCV) infections.
Objective: Point this study is to assess job serum epidermal development factor like space 7 as a demonstrative marker in HCC Egyptian cirrhotic patients.
Methods: A total of 90 subjects were enrolled in this study, categorized into two groups: group A (HCC), comprising 45 patients with Hepatocellular carcinoma, and group B (Cirrhotic), comprising 45 patients with liver cirrhosis without HCC. The study subjects underwent history taking, physical examination, routine laboratory tests, measurement of AFP and EGFL7 levels, and radiological evaluations.
Results: EGFL7, a molecule with signaling and EGF-like domains, was significantly upregulated in HCC tissues compared to cirrhotic tissues. High EGFL7 expression was associated with adverse clinicopathological features and poor prognosis in HCC patients. The study demonstrated that EGFL7 exhibited higher diagnostic performance in distinguishing between cirrhosis and HCC compared to AFP. Moreover, EGFL7 levels were positively correlated with the Child-Pugh score and the size of hepatic lesions in the HCC group.
Conclusion: This research highlights that serum EGFL7 is substantially elevated in HCC patients, particularly those with co-existing conditions such as diabetes, hypertension, or viral markers. EGFL7 emerges as a more sensitive and accurate marker than AFP for early HCC detection. Incorporating EGFL7 into diagnostic algorithms could enhance the effectiveness of surveillance programs for early HCC detection, ultimately leading to improved clinical outcomes and patient management