الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
The earlier assessment of predictive factors that predict the response to NAC would permit a tailored approach in selecting the initial therapy that may yield the best clinical and pathological response and subsequent better OS. A great number of studies have shown that Ki-67 is a factor that can predict the response to NAC. However, despite the increasing evidence showing the predictive value of Ki-67, it’s not clear whether Ki-67 is identically helpful for predictive approaches. Many studies reported a significant relationship between Ki-67 expression and response to NAC while other studies didn’t find any positive relationships between Ki-67 expression and pCR.
Our study evaluated whether pretreatment Ki-67 levels were able to predict both clinical and pathological response with the administration of the same NAC regimen. Furthermore, we investigated the change of Ki-67 expression between the core needle biopsy and the residual tumor on surgical specimen. This study demonstrated that pretreatment Ki-67 level weren’t able to play a predictive role in predicting both cCR and pCR to NAC. This may be due to small sample size in our study due to limited number of patients who had assessment for Ki-67 levels on both pretreatment core biopsy and post treatment surgical specimen. Also, our study also showed that there is significant change in Ki-67 expression between core biopsy and surgical specimen after NAC.